Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces.

Gustafson, Margaret A; Perera, Lalith; Shi, Min; Copeland, William C

Gustafson, Margaret A; Perera, Lalith; Shi, Min; Copeland, William C.

Afiliación

Gustafson MA; Mitochondrial DNA Replication Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.
Perera L; Computational Chemistry and Molecular Modeling Support Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.
Shi M; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.
Copeland WC; Mitochondrial DNA Replication Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA. Electronic address: copelan1@niehs.nih.gov.

DNA Repair (Amst) ; 107: 103212, 2021 11.

Article en En | MEDLINE | ID: mdl-34464898

Asunto(s)

Simulación de Dinámica Molecular

Palabras clave

Human disease variants; Mitochondrial DNA replication; Molecular modeling; Single stranded DNA binding protein; mtSSB

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simulación de Dinámica Molecular Tipo de estudio: Prognostic_studies Idioma: En Revista: DNA Repair (Amst) Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google