Breast cancer risk in relation to type of estrogen contained in oral contraceptives.
Contraception
; 36(6): 595-613, 1987 Dec.
Article
en En
| MEDLINE
| ID: mdl-3446437
ABSTRACT
PIP: This report present analyses addressing the recent hypothesis that women who use combination-type oral contraceptives (OC) containing ethinylestradiol (EE) are at increased risk of breast cancer before age 45, if they use OCs before the 1st term of pregnancy (FTP). Our findings, based on data from 1679 controls, 20-44 years of age, from the population-based Cancer and Steroid Hormone Study, are against the hypothesis. The relative risk of breast cancer by duration of exclusive use prior to FTP of OCs containing EE is estimated to be 1.0 (1-12 months EE use), 1.2 (13-48 months EE use), and 0.9 (49+ months EE use). There was no evidence of a latent effect. Among parous women with the 49+ months exclusive use prior to FTP of EE-containing OCs, the relative risk of breast cancer was estimated as 0.9 (0-4 years after FTP) and 0.6 (5-9 years after FTP). Among nulliparous women with 49+ months exclusive use of EE-containing OCs, the relative risk of breast cancer was estimated as 1.0 (0-4) years since 1st use), 0.7 (5-9 years since 1st use), and 1.1 (0-4 years since 1st use). With regard to exclusive use of OCs containing mestranol (ME); parous women who used such preparations long-term before their FTP showed no alteration of breast cancer risk, even 15 years or more after pregnancy. Nulliparous women with exclusive use of ME containing OCs did show elevations in breast cancer risk, but the magnitude of risk in relation to duration of use and latent interval show no pattern that suggests a cause-effect relationship.
Palabras clave
Americas; Biology; Birth Intervals; Breast Cancer; Cancer; Contraception--side effects; Contraceptive Agents, Estrogen--side effects; Contraceptive Agents, Female--side effects; Contraceptive Agents--side effects; Contraceptive Methods--side effects; Correlation Studies; Demographic Factors; Developed Countries; Developing Countries; Diseases; Endocrine System; Epidemiologic Methods; Ethinyl Estradiol--side effects; Family Planning; Fertility; Fertility Measurements; First Birth Intervals; Hormones; Longterm Effects; Mestranol--side effects; Neoplasms; North America; Northern America; Oral Contraceptives--side effects; Parity; Physiology; Population; Population Dynamics; Research Methodology; Research Report; Statistical Studies; Studies; Time Factors; United States
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Anticonceptivos Orales Combinados
/
Etinilestradiol
/
Mestranol
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos