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NEAT1 and MALAT1 are highly expressed in saliva and nasopharyngeal swab samples of COVID-19 patients.
Rodrigues, Ana Carolina; Adamoski, Douglas; Genelhould, Gustavo; Zhen, Felipe; Yamaguto, Guilherme Eiji; Araujo-Souza, Patrícia Savio; Nogueira, Meri Bordignon; Raboni, Sonia Mara; Bonatto, Ana Claudia; Gradia, Daniela Fiori; Carvalho de Oliveira, Jaqueline.
Afiliación
  • Rodrigues AC; Departamento de Genética, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Adamoski D; Programa de Pos-graduação em Genética, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Genelhould G; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Sao Paulo, Brazil.
  • Zhen F; Programa de Pos-graduação em Genética, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Yamaguto GE; Laboratório de Virologia, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Araujo-Souza PS; Unidade de Infectologia, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Nogueira MB; Unidade de Infectologia, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Raboni SM; Departamento de Genética, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Bonatto AC; Programa de Pos-graduação em Genética, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Gradia DF; Laboratório de Virologia, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Carvalho de Oliveira J; Laboratório de Virologia, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Mol Oral Microbiol ; 36(6): 291-294, 2021 12.
Article en En | MEDLINE | ID: mdl-34463043
COVID-19, caused by the SARS-CoV-2 virus, has become a significant global public health problem, with a wide variety of clinical manifestations and disease progression outcomes. LncRNAs are key regulators of the immune response and have been associated with COVID-19 risk infection. Previous studies focused mainly on in-silico analysis of lncRNA expression in the lungs or peripheral blood cells. We evaluated the expression of lncRNAs NEAT1, MALAT1, and MIR3142 in saliva and nasopharyngeal swab from SARS-CoV-2 positive (n = 34) and negative patients (n = 46). A higher expression of the lncRNAs NEAT1 and MALAT1 (p < 0.05) were found in positive samples. NEAT1 had a higher expression mainly in saliva samples (p < 0.001), and MALAT1 was upregulated in nasopharyngeal samples (p < 0.05). Area under the ROC curve for NEAT1 in saliva was 0.8067. This study was the first to investigate the expression of lncRNAs in saliva and nasopharyngeal samples of COVID-19 patients, which gives new insights into the initial response to infection and infectivity and may provide new biomarkers for severity and targets for therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / ARN Largo no Codificante / COVID-19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Oral Microbiol Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / ARN Largo no Codificante / COVID-19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Oral Microbiol Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Dinamarca