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Lack of Association between Monocyte Chemoattractant Protein-1 (MCP-1) Gene Promoter Polymorphism and Behcet's Disease with and without Ocular Involvement in Iranian Population: A Case-Control Study.
Ghaffari Laleh, Maryam; Bonyadi, Mortaza; Shahriyari, Elham; Jabbarpoor Bonyadi, Mohammad Hossein; Soheilian, Masoud; Yaseri, Mehdi.
Afiliación
  • Ghaffari Laleh M; Faculty of Natural Sciences, Center of Excellence for Biodiversity, University of Tabriz, Tabriz, Iran.
  • Bonyadi M; Faculty of Natural Sciences, Center of Excellence for Biodiversity, University of Tabriz, Tabriz, Iran.
  • Shahriyari E; Faculty of Natural Sciences, Center of Excellence for Biodiversity, University of Tabriz, Tabriz, Iran.
  • Jabbarpoor Bonyadi MH; Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Soheilian M; Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Yaseri M; Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran.
Curr Eye Res ; 47(2): 312-316, 2022 02.
Article en En | MEDLINE | ID: mdl-34459335
PURPOSE: This case-control study aimed to evaluate the possible association of MCP-1 - 2518A/G genetic polymorphism with Behcet's disease (BD) in the Iranian patients. MATERIALS AND METHODS: This study was performed in 135 Behcet's patients (51 ocular and 84 non-ocular) and 79 healthy individuals. Peripheral blood samples were genotyped for MCP-1 - 2518A/G using the PCR-RFLP technique. RESULTS: The statistical analysis of MCP-1 - 2518A/G showed no significant differences in genotype/allele frequencies between Behcet's patients and controls. There was no significant association in genotype/allele frequencies between either ocular or non-ocular BD patients and controls. Also, different genotype/allele frequencies between ocular and non-ocular BD were not statistically significant. CONCLUSIONS: In this study, with a threshold P-value of 0.05 and an estimated power of 0.81 to detect a significant association (odds ratio ≥1.2), we did not observe any association of this variant with Behcet's disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Behçet / Quimiocina CCL2 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Curr Eye Res Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Behçet / Quimiocina CCL2 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Curr Eye Res Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido