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Prion strains associated with iatrogenic CJD in French and UK human growth hormone recipients.
Douet, Jean-Yves; Huor, Alvina; Cassard, Hervé; Lugan, Séverine; Aron, Naïma; Mesic, Chloé; Vilette, Didier; Barrio, Tomás; Streichenberger, Nathalie; Perret-Liaudet, Armand; Delisle, Marie-Bernadette; Péran, Patrice; Deslys, Jean-Philippe; Comoy, Emmanuel; Vilotte, Jean-Luc; Goudarzi, Katayoun; Béringue, Vincent; Barria, Marcelo A; Ritchie, Diane L; Ironside, James W; Andréoletti, Olivier.
Afiliación
  • Douet JY; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Huor A; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Cassard H; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Lugan S; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Aron N; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Mesic C; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Vilette D; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Barrio T; UMR INRAE ENVT 1225, Interactions Hôtes-Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076, Toulouse, France.
  • Streichenberger N; BIORAN Team, Lyon Neuroscience Research Center, CNRS UMR 5292 - INSERM U1028, Université de Lyon - Université Claude Bernard, Lyon, France.
  • Perret-Liaudet A; Neurochemistry Laboratory, Biochemistry Department, Centre de Pathologie et Neuropathologie Est, Hospices Civils de Lyon, Bron, France.
  • Delisle MB; BIORAN Team, Lyon Neuroscience Research Center, CNRS UMR 5292 - INSERM U1028, Université de Lyon - Université Claude Bernard, Lyon, France.
  • Péran P; Neurochemistry Laboratory, Biochemistry Department, Centre de Pathologie et Neuropathologie Est, Hospices Civils de Lyon, Bron, France.
  • Deslys JP; Laboratoire Universitaire d'Anatomie Pathologique, INSERM U 1214 TONIC, CHU Purpan, C.H.U. Rangueil - 1 Avenue Jean Poulhès, 50032 - 31059, Toulouse Cedex9, TSA, France.
  • Comoy E; Laboratoire Universitaire d'Anatomie Pathologique, INSERM U 1214 TONIC, CHU Purpan, C.H.U. Rangueil - 1 Avenue Jean Poulhès, 50032 - 31059, Toulouse Cedex9, TSA, France.
  • Vilotte JL; CEA, Service d'Etude des Prions et des Infections Atypiques, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
  • Goudarzi K; CEA, Service d'Etude des Prions et des Infections Atypiques, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
  • Béringue V; INRAE, AgroParistech, GABI, Université Paris-Saclay, Jouy-en-Josas, France.
  • Barria MA; INRAE, AgroParistech, GABI, Université Paris-Saclay, Jouy-en-Josas, France.
  • Ritchie DL; INRAE, UVSQ, VIM, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
  • Ironside JW; National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Centre for Clinical Brain Sciences, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Andréoletti O; National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Centre for Clinical Brain Sciences, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Acta Neuropathol Commun ; 9(1): 145, 2021 08 28.
Article en En | MEDLINE | ID: mdl-34454616
Treatment with human pituitary-derived growth hormone (hGH) was responsible for a significant proportion of iatrogenic Creutzfeldt-Jakob disease (iCJD) cases. France and the UK experienced the largest case numbers of hGH-iCJD, with 122 and 81 cases respectively. Differences in the frequency of the three PRNP codon 129 polymorphisms (MM, MV and VV) and the estimated incubation periods associated with each of these genotypes in the French and the UK hGH-iCJD cohorts led to the suggestion that the prion strains responsible for these two hGH-iCJD cohorts were different. In this study, we characterized the prion strains responsible for hGH-iCJD cases originating from UK (n = 11) and France (n = 11) using human PrP expressing mouse models. The cases included PRNP MM, MV and VV genotypes from both countries. UK and French sporadic CJD (sCJD) cases were included as controls. The prion strains identified following inoculation with hGH-iCJD homogenates corresponded to the two most frequently observed sCJD prion strains (M1CJD and V2CJD). However, in clear contradiction to the initial hypothesis, the prion strains that were identified in the UK and the French hGH-iCJD cases were not radically different. In the vast majority of the cases originating from both countries, the V2CJD strain or a mixture of M1CJD + V2CJD strains were identified. These data strongly support the contention that the differences in the epidemiological and genetic profiles observed in the UK and France hGH-iCJD cohorts cannot be attributed only to the transmission of different prion strains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Creutzfeldt-Jakob / Encefalopatía Espongiforme Bovina / Proteínas PrPSc / Hormona de Crecimiento Humana Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Neuropathol Commun Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Creutzfeldt-Jakob / Encefalopatía Espongiforme Bovina / Proteínas PrPSc / Hormona de Crecimiento Humana Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Neuropathol Commun Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido