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Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels.
Reque, Regiane; Carneiro, Rhaissa Dayane; Yamamoto, Flávia Yoshie; Ramsdorf, Wanessa Algarte; Martins, Lucia Regina; Guiloski, Izonete Cristina; de Freitas, Adriane Martins.
Afiliación
  • Reque R; Laboratory of Ecotoxicology, Department of Chemistry and Biology, Federal University of Technology - Paraná, Curitiba, Paraná, Brazil.
  • Carneiro RD; Laboratory of Ecotoxicology, Department of Chemistry and Biology, Federal University of Technology - Paraná, Curitiba, Paraná, Brazil.
  • Yamamoto FY; Institute of Biosciences, State University of São Paulo, São Vicente, São Paulo, Brazil.
  • Ramsdorf WA; Laboratory of Ecotoxicology, Department of Chemistry and Biology, Federal University of Technology - Paraná, Curitiba, Paraná, Brazil.
  • Martins LR; Laboratory of Ecotoxicology, Department of Chemistry and Biology, Federal University of Technology - Paraná, Curitiba, Paraná, Brazil.
  • Guiloski IC; Research Institute Pelé Pequeno Príncipe, Curitiba, Paraná, Brazil; Faculdades Pequeno Príncipe, Curitiba, Paraná, Brazil.
  • de Freitas AM; Laboratory of Ecotoxicology, Department of Chemistry and Biology, Federal University of Technology - Paraná, Curitiba, Paraná, Brazil. Electronic address: adrianefreitas@utfpr.edu.br.
Environ Toxicol Pharmacol ; 87: 103727, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34454063
The intensive use of the antihypertensive losartan potassium (LOS) has culminated in its high occurrence in aquatic environments. However, insufficient studies had investigated its effects in non-target organisms. In this study, ecotoxicity of LOS was assessed in aquatic organisms from distinct trophic levels (Desmodesmus subspicatus, Daphnia magna, and Astyanax altiparanae). Genotoxicity was assessed by the comet assay in D. magna and A. altiparanae, and biochemical biomarkers for the fish. LOS was more toxic to D. subspicatus (EC50(72h) = 27.93 mg L-1) than D. magna (EC50 = 303.69 mg L-1). Subsequently, this drug showed to induce more DNA damage in D. magna than A. altiparanae, when exposed to 2.5 mg L-1. No significant stress responses were observed by the fish biomarkers, suggesting that higher trophic levels organisms are more tolerant to LOS toxicity. LOS showed relatively low toxic potential for a short period of exposure, but with different patterns of toxicity for the organisms from distinct trophic levels, contributing to further risk assessment of LOS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Losartán / Antihipertensivos Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Losartán / Antihipertensivos Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos