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Bacteriophage Therapy for Difficult-to-Treat Infections: The Implementation of a Multidisciplinary Phage Task Force (The PHAGEFORCE Study Protocol).
Onsea, Jolien; Uyttebroek, Saartje; Chen, Baixing; Wagemans, Jeroen; Lood, Cédric; Van Gerven, Laura; Spriet, Isabel; Devolder, David; Debaveye, Yves; Depypere, Melissa; Dupont, Lieven; De Munter, Paul; Peetermans, Willy E; van Noort, Vera; Merabishvili, Maia; Pirnay, Jean-Paul; Lavigne, Rob; Metsemakers, Willem-Jan.
Afiliación
  • Onsea J; Department of Trauma Surgery, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Uyttebroek S; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
  • Chen B; Department of Otorhinolaryngology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Wagemans J; Department of Neurosciences, Experimental Otorhinolaryngology, Rhinology Research, KU Leuven, 3000 Leuven, Belgium.
  • Lood C; Department of Trauma Surgery, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Van Gerven L; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
  • Spriet I; Department of Biosystems, Laboratory of Gene Technology, KU Leuven, 3000 Leuven, Belgium.
  • Devolder D; Department of Biosystems, Laboratory of Gene Technology, KU Leuven, 3000 Leuven, Belgium.
  • Debaveye Y; Center of Microbial and Plant Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Depypere M; Department of Otorhinolaryngology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Dupont L; Department of Neurosciences, Experimental Otorhinolaryngology, Rhinology Research, KU Leuven, 3000 Leuven, Belgium.
  • De Munter P; Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, 3000 Leuven, Belgium.
  • Peetermans WE; Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.
  • van Noort V; Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, 3000 Leuven, Belgium.
  • Merabishvili M; Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Pirnay JP; Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, 3000 Leuven, Belgium.
  • Lavigne R; Department of Intensive Care Medicine, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Metsemakers WJ; Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, Belgium.
Viruses ; 13(8)2021 08 05.
Article en En | MEDLINE | ID: mdl-34452408
In times where only a few novel antibiotics are to be expected, antimicrobial resistance remains an expanding global health threat. In case of chronic infections caused by therapy-resistant pathogens, physicians have limited therapeutic options, which are often associated with detrimental consequences for the patient. This has resulted in a renewed interest in alternative strategies, such as bacteriophage (phage) therapy. However, there are still important hurdles that currently impede the more widespread implementation of phage therapy in clinical practice. First, the limited number of good-quality case series and clinical trials have failed to show the optimal application protocol in terms of route of administration, frequency of administration, treatment duration and phage titer. Second, there is limited information on the systemic effects of phage therapy. Finally, in the past, phage therapy has been applied intuitively in terms of the selection of phages and their combination as parts of phage cocktails. This has led to an enormous heterogeneity in previously published studies, resulting in a lack of reliable safety and efficacy data for phage therapy. We hereby present a study protocol that addresses these scientific hurdles using a multidisciplinary approach, bringing together the experience of clinical, pharmaceutical and molecular microbiology experts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Terapia de Fagos / Infección Persistente / Implementación de Plan de Salud Tipo de estudio: Guideline / Sysrev_observational_studies Aspecto: Implementation_research Límite: Humans Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Terapia de Fagos / Infección Persistente / Implementación de Plan de Salud Tipo de estudio: Guideline / Sysrev_observational_studies Aspecto: Implementation_research Límite: Humans Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza