Your browser doesn't support javascript.
loading
The Use of Real-World Data to Evaluate the Association Between Atopic Dermatitis and Cardiovascular Disease: A Retrospective Claims Analysis.
Wu, Jashin J; Amand, Caroline; No, Daniel J; Mahajan, Puneet; Gadkari, Abhijit; Ghorayeb, Eric; Kaur, Mandeep; Korotzer, Andrew; Eckert, Laurent.
Afiliación
  • Wu JJ; Dermatology Research and Education Foundation, Irvine, CA, USA. jashinwu@gmail.com.
  • Amand C; Sanofi, 1 Avenue Pierre Brossolette, 91380, Chilly-Mazarin, France.
  • No DJ; Department of Dermatology, Kaiser Permanente Los Angeles Medical Center, 1515 N. Vermont Ave. 5th Floor, Los Angeles, CA, 90027, USA.
  • Mahajan P; Sanofi, 55 Corporate Drive, Bridgewater, NJ, 08807, USA.
  • Gadkari A; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY, 12533, USA.
  • Ghorayeb E; Sanofi, 55 Corporate Drive, Bridgewater, NJ, 08807, USA.
  • Kaur M; Sanofi, 50 Binney Street, Cambridge, MA, 02138, USA.
  • Korotzer A; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY, 12533, USA.
  • Eckert L; Sanofi, 1 Avenue Pierre Brossolette, 91380, Chilly-Mazarin, France.
Dermatol Ther (Heidelb) ; 11(5): 1707-1715, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34449070
INTRODUCTION: Atopic dermatitis (AD) is a systemic inflammatory condition that may increase the risk of cardiovascular disease (CVD); however, ongoing debate exists surrounding its direct association. We aimed to elucidate whether AD contributes to a higher incidence of CVD and major adverse cardiovascular events (MACE) in adult patients with AD, independent of metabolic disorders. METHODS: We retrospectively analyzed a large US-based population of patients with AD (≥ 18 years of age). Logistic regression estimated the risk of CVD and MACE in adult patients with AD, independent of metabolic disorders (including diabetes, hypertension, and obesity). RESULTS: The odds ratio (OR; 95% confidence interval [CI]) for patients without metabolic disorders was 1.25 (1.13, 1.39) for CVD and 1.22 (1.01, 1.47) for MACE. The OR (95% CI) for AD patients with metabolic disorders was 1.09 (1.07, 1.12) for CVD and 1.14 (1.09, 1.18) for MACE. This trend was even more pronounced after long-term follow-up (≥ 3 years). Lifestyle and health behavioral factors of the subjects were not available in the dataset. The lack of control for these factors could potentially confound our results. CONCLUSIONS: Atopic dermatitis may contribute to the risk of developing CVD and MACE in adults, independent of metabolic disorders.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Dermatol Ther (Heidelb) Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Dermatol Ther (Heidelb) Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza