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Stability study of the antiviral agent camphecene in dried blood spots at different temperatures.
Okhina, Alina A; Rogachev, Artem D; Yarovaya, Olga I; Pokrovsky, Andrey G; Salakhutdinov, Nariman F.
Afiliación
  • Okhina AA; Department of Medicinal chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russia.
  • Rogachev AD; V. Zelman Institute for Medicine and Psychology, Novosibirsk State University, Novosibirsk, Russia.
  • Yarovaya OI; Department of Medicinal chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russia.
  • Pokrovsky AG; V. Zelman Institute for Medicine and Psychology, Novosibirsk State University, Novosibirsk, Russia.
  • Salakhutdinov NF; Department of Medicinal chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russia.
Drug Test Anal ; 13(10): 1797-1802, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34448348
In this study, an optimized procedure of sample preparation for quantitative determination of the antiviral agent camphecene in dried rat blood spots was developed. It has been shown that when using methanol containing 0.1% HCOOH as an extractant, the recovery of the substance increases in comparison with the previously developed method. In addition to this, there is no need to dilute the obtained solutions with water for the analysis of the sample by high-performance liquid chromatography (HPLC) on a column with a reversed-phase sorbent. By using the developed method, the stability of samples of dried rat blood spots containing camphecene in different concentrations at different temperatures was studied. It was found that while the samples were stored at room temperature, apparently, desorption of the substance occurs leading to a loss of more than 15% of its initial amount after 5-10 days. Lowering the temperature increases the stability of samples and their storage at -70°C is possible for 4 weeks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Alcanfor / Cromatografía Líquida de Alta Presión / Etanolaminas / Pruebas con Sangre Seca Límite: Animals Idioma: En Revista: Drug Test Anal Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Alcanfor / Cromatografía Líquida de Alta Presión / Etanolaminas / Pruebas con Sangre Seca Límite: Animals Idioma: En Revista: Drug Test Anal Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido