Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine <i>Rhodococcus</i>.

Palma Esposito, Fortunato; Giugliano, Rosa; Della Sala, Gerardo; Vitale, Giovanni Andrea; Buonocore, Carmine; Ausuri, Janardhan; Galasso, Christian; Coppola, Daniela; Franci, Gianluigi; Galdiero, Massimiliano; de Pascale, Donatella

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine Rhodococcus.

Palma Esposito, Fortunato; Giugliano, Rosa; Della Sala, Gerardo; Vitale, Giovanni Andrea; Buonocore, Carmine; Ausuri, Janardhan; Galasso, Christian; Coppola, Daniela; Franci, Gianluigi; Galdiero, Massimiliano; de Pascale, Donatella.

Afiliación

Palma Esposito F; Department of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Giugliano R; Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Della Sala G; Department of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Vitale GA; Department of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Buonocore C; Department of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Ausuri J; Institute of Biochemistry and Cell Biology, National Research Council, 80131 Naples, Italy.
Galasso C; Institute of Biochemistry and Cell Biology, National Research Council, 80131 Naples, Italy.
Coppola D; Department of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Franci G; Department of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Galdiero M; Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
de Pascale D; Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Int J Mol Sci ; 22(16)2021 Aug 22.

Article en En | MEDLINE | ID: mdl-34445761

Asunto(s)

Antivirales/metabolismo; Glucolípidos/metabolismo; Rhodococcus/metabolismo; Animales; Antivirales/análisis; Chlorocebus aethiops; Técnicas de Cultivo; Ensayos de Selección de Medicamentos Antitumorales; Ésteres/metabolismo; Genoma Bacteriano; Glucolípidos/química; Humanos; Metaboloma; Pruebas de Sensibilidad Microbiana; Estructura Molecular; Células PC-3; Rhodococcus/química; Rhodococcus/genética; Succinatos/metabolismo; Tensoactivos/química; Tensoactivos/metabolismo; Células Vero

Palabras clave

OSMAC approach; antiproliferative; antiviral; biosurfactant; glycolipids; marine bacteria; mass spectrometry; metabolomics; microbial natural products; trehalolipids

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Rhodococcus / Glucolípidos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza

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