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Versatile Functionalization of P25 Conjugated ND Nanocomposites for UV-Mediated Free Radical Scavenging and Facilitates Anti-Inflammation Potential in Human Cells.
Chen, Yi-Lun; Lee, Guang-Yu; Sung, Ming-Yen; Huang, Jen-Hsien; Cho, Er-Chieh; Lee, Kuen-Chan.
Afiliación
  • Chen YL; Department of Science Education, National Taipei University of Education, No.134, Sec. 2, Heping E. Rd., Da-an District, Taipei City 106, Taiwan.
  • Lee GY; Department of Science Education, National Taipei University of Education, No.134, Sec. 2, Heping E. Rd., Da-an District, Taipei City 106, Taiwan.
  • Sung MY; School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wuxing Street, Taipei City, 110, Taiwan.
  • Huang JH; Department of Green Material Technology, Green Technology Research Institute, CPC Corporation, Kaohsiung 81126, Taiwan.
  • Cho EC; School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wuxing Street, Taipei City, 110, Taiwan.
  • Lee KC; Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, 250 Wuxing Street, Taipei City, 110, Taiwan.
ACS Appl Mater Interfaces ; 13(33): 39088-39099, 2021 Aug 25.
Article en En | MEDLINE | ID: mdl-34433242
In this work, we demonstrated that building different linking groups between nanodiamond (ND) and TiO2 (P25) could provide more effective protection under oxidative stress and ultraviolet (UV) light irradiation compared with the use of TiO2 alone. The establishment of ester (-C-O-O-R), amide (-CONH-), and epoxide-amine adduct (-NHCCO-) groups between ND-TiO2 composites was found to be critical in the generation of reactive oxygen species (ROS) by controlling their charge transfer behaviors. We hypothesized that linking groups between the composites dictate the performance of ROS generation from nano-TiO2 under UV-light irradiation due to the differences in linking groups. The results showed that hydroxyl radicals were attenuated by the incorporation of ND. An MTT cell proliferation assay was performed in human cells under the treatment of ND-TiO2 composites to investigate the impacts of composites on cell viability. The results from the luciferase reporter assay suggested they have anti-inflammatory activity and can reduce cellular DNA damage under ROS stimulation. A zebrafish model was also applied with the ND-TiO2 composite treatment to demonstrate the safety aspects of the composites in vivo and their biomedical application potential. Studies exploring ROS generation behaviors in different linking groups suggested that interactive functionalization between nanoparticles might be an ideal antioxidant and anti-inflammatory strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Titanio / Depuradores de Radicales Libres / Nanocompuestos / Nanodiamantes / Antiinflamatorios Límite: Animals / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Titanio / Depuradores de Radicales Libres / Nanocompuestos / Nanodiamantes / Antiinflamatorios Límite: Animals / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos