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Antidepressant effect of electroacupuncture on modulating the expression of c-Fos/AP-1 through the JNK signaling pathway.
Li, Xiang; Qi, Si-Min; Wang, Yu; Jiang, Hui-Wu; Li, Ya-Huan; Zhao, Bing-Cong; Zhang, Tao; Sun, Yang; Gao, Xing-Zhou; Quan, Song-Xiao; Liu, Peng-Fei; Li, Wen-Shan; Wu, Ji-Hong; Bao, Tu-Ya; Jiang, Hui-Li.
Afiliación
  • Li X; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Qi SM; Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Wang Y; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Jiang HW; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
  • Li YH; School of Health Management, Xi'an Medical University, Xi'an, China.
  • Zhao BC; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Zhang T; Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Sun Y; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
  • Gao XZ; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
  • Quan SX; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Liu PF; Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Li WS; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Wu JH; Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Bao TY; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Jiang HL; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Anat Rec (Hoboken) ; 304(11): 2480-2493, 2021 11.
Article en En | MEDLINE | ID: mdl-34431619
The effectiveness and safety of electroacupuncture (EA) for depression have been identified by abundant clinical trials and experimental findings. The c-Jun-NH(2)-terminal kinase (JNK) signaling pathway is considered to be involved in the antidepressant mechanism of EA. However, the antidepressant effect of EA via modulating the expression of c-Fos/activator protein-1 (AP-1) under the condition of JNK inhibition remains unexplored. In this study, we investigated the antidepressant effect and possible mechanism of EA in regulating the expression of c-Fos/AP-1 under the condition of JNK inhibition by SP600125 in rats exposed to chronic unpredictable mild stress (CUMS). The depression-like behaviors were evaluated by the body weight, sucrose preference test (SPT), and open field test (OFT). The expression levels of c-Jun in the hypothalamus, c-Fos in the pituitary gland, and c-Fos and AP-1 in the serum of CUMS induced rat model of depression were detected by ELISA. The results indicated that treatment with EA and fluoxetine can reverse the CUMS-induced depression-like behaviors in rats and can up-regulate the expression levels of c-Jun in the hypothalamus, c-Fos in the pituitary gland, and c-Fos and AP-1 in the serum. Of note, the data demonstrated that SP600125, the inhibitor of JNK signaling pathway, can exert synergistic effect with EA in regulating CUMS-induced abnormal activation of the JNK signaling pathway. The antidepressant effect of EA might be mediated by modulating the expression of c-Fos/AP-1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Proteínas Proto-Oncogénicas c-fos / Factor de Transcripción AP-1 / Sistema de Señalización de MAP Quinasas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anat Rec (Hoboken) Asunto de la revista: ANATOMIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Proteínas Proto-Oncogénicas c-fos / Factor de Transcripción AP-1 / Sistema de Señalización de MAP Quinasas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anat Rec (Hoboken) Asunto de la revista: ANATOMIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos