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Antidepressant Monotherapy and Combination Therapy with Acupuncture in Depressed Patients: A Resting-State Functional Near-Infrared Spectroscopy (fNIRS) Study.
Wong, Yat Kwan; Wu, Jun Mei; Zhou, Guodong; Zhu, Frank; Zhang, Quan; Yang, Xin Jing; Qin, Zongshi; Zhao, Ni; Chen, Haiyong; Zhang, Zhang-Jin.
Afiliación
  • Wong YK; School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
  • Wu JM; School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
  • Zhou G; Acupucture and Tuina college, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Zhu F; Department of Electronic Engineering, The Chinese University of Hong Kong, New Territories, Hong Kong, China.
  • Zhang Q; Unique Mind Centre, Central, Hong Kong, China.
  • Yang XJ; Neural Systems Group, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA.
  • Qin Z; School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
  • Zhao N; School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
  • Chen H; Department of Electronic Engineering, The Chinese University of Hong Kong, New Territories, Hong Kong, China.
  • Zhang ZJ; School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China. haiyong@hku.hk.
Neurotherapeutics ; 18(4): 2651-2663, 2021 10.
Article en En | MEDLINE | ID: mdl-34431029
Depression is a common psychiatric illness affecting over 300 million people globally. Acupuncture has been reported to be a safe complementary treatment for depression. This study is aimed to investigate the efficacy and mechanism of combining acupuncture with antidepressants in treating depression compared to the sole use of antidepressants. Seventy depression patients were randomly assigned to the treatment group (n = 50) and control group (n = 20). The treatment group received acupuncture combined antidepressants treatment for 3 weeks, while the control group took antidepressants monotherapy for 3 weeks. Among the 70 patients, 40 participants (20 control; 20 treatment) were randomized for studying functional connectivity (FC) of the dorsolateral prefrontal cortex (DLPFC) measured by the functional near-infrared spectroscopy. The primary outcome was HAMD-17 and secondary outcomes were PHQ-9, and the relationships of resting-state FC (rsFC) with the depression severity. PHQ-9 and HAMD-17 scores in the treatment group were significantly lower than those in the control group at Week 3 (p = 0.01) with effect sizes of -0.4 and -0.61 respectively. The rsFC in F1, F3, AF3, AF7, FC3, FC5 (left DLPFC, 10-20 system), AF8, and F6 (right DLPFC) in the treatment group had significant temporal correlation (p < 0.05, FDR corrected) in DLPFC compared to the channels in the control group. No significant correlation was found between the changes of rsFC and depression severity. In conclusion, depressed patients receiving acupuncture combined with antidepressants have improvement of depressive symptoms and the stronger rsFC in the DLPFC compared to those using antidepressants alone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia por Acupuntura / Espectroscopía Infrarroja Corta Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Neurotherapeutics Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia por Acupuntura / Espectroscopía Infrarroja Corta Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Neurotherapeutics Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos