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Effectiveness of Convalescent Plasma Therapy in Severe or Critically Ill COVID-19 Patients: A Retrospective Cohort Study.
Cho, YunSuk; Sohn, YuJin; Hyun, JongHoon; Baek, YaeJee; Kim, MooHyun; Kim, JungHo; Ahn, JinYoung; Jeong, SuJin; Ku, NamSu; Yeom, Joon Sup; Ahn, MiYoung; Oh, DongHyun; Choi, JaePhil; Kim, SinYoung; Lee, KyoungHwa; Song, YoungGoo; Choi, JunYong.
Afiliación
  • Cho Y; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Sohn Y; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Hyun J; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Baek Y; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Kim M; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Kim J; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Ahn J; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Jeong S; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Ku N; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Yeom JS; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Ahn M; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Oh D; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Choi J; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Kim S; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Lee K; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Song Y; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Choi J; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J ; 62(9): 799-805, 2021 Sep.
Article en En | MEDLINE | ID: mdl-34427065
PURPOSE: Coronavirus disease-2019 (COVID-19) is a novel respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); there are few specific treatments. Convalescent plasma (CP), donated by people who have recovered from COVID-19, is an investigational therapy for severe or critically ill patients with COVID-19. MATERIALS AND METHODS: This retrospective cohort study evaluated the effectiveness of CP therapy in patients with severe or life-threatening cases of COVID-19 at two hospitals in Seoul, Korea, between May and September 2020. Clinical outcomes were evaluated in 20 patients with CP therapy in a descriptive manner. Additionally, the changes in cycle threshold (Ct) values of 10 patients with CP therapy were compared to those of 10 controls who had the same (±0.8) initial Ct values but did not receive CP. RESULTS: Of the 20 patients (mean age 66.6 years), 18 received high-dose oxygen therapy using mechanical ventilators or high-flow nasal cannulas. Systemic steroids were administered to 19 patients who received CP. The neutralizing antibody titers of the administered CP were between 1:80 and 1:10240. There were two ABO-mismatched transfusions. The World Health Organization ordinal scale score and National Institutes of Health severity score improved in half of the patients within 14 days. Those who received CP showed a higher increase in Ct values at 24 h and 72 h after CP therapy compared to controls with similar initial Ct values (p=0.002). No transfusion-related side effects were observed. CONCLUSION: CP therapy may be a potential therapeutic option in severe or critically ill patients with COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunización Pasiva / COVID-19 Tipo de estudio: Etiology_studies / Observational_studies Límite: Aged / Humans País/Región como asunto: America do norte Idioma: En Revista: Yonsei Med J Año: 2021 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunización Pasiva / COVID-19 Tipo de estudio: Etiology_studies / Observational_studies Límite: Aged / Humans País/Región como asunto: America do norte Idioma: En Revista: Yonsei Med J Año: 2021 Tipo del documento: Article Pais de publicación: Corea del Sur