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OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis.
Li, Tian; Yang, Xin-Yu; Xu, Ding-Jie; Gao, Zi-Yi; Gao, Yi-Bing; Jin, Fu-Yu; Li, Ya-Qian; Liu, Shu-Peng; Li, Shi-Feng; Gao, Xue-Min; Cai, Wen-Chen; Mao, Na; Wei, Zhong-Qiu; Liu, He-Liang; Sun, Ying; Yang, Fang; Xu, Hong.
Afiliación
  • Li T; Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Yang XY; Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Xu DJ; Traditional Chinese Medicine College, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Gao ZY; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Gao YB; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Jin FY; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Li YQ; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Liu SP; Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Li SF; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Gao XM; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Cai WC; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Mao N; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Wei ZQ; Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Liu HL; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Sun Y; Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Yang F; School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
  • Xu H; Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province 063210, China.
Oxid Med Cell Longev ; 2021: 4158495, 2021.
Article en En | MEDLINE | ID: mdl-34426759
Cellular senescence has been considered an important driver of many chronic lung diseases. However, the specific mechanism of cellular senescence in silicosis is still unknown. In the present study, silicotic rats and osteoclast stimulatory transmembrane protein (Ocstamp) overexpression of MLE-12 cells were used to explore the mechanism of OC-STAMP in cellular senescence in alveolar epithelial cell type II (AEC2). We found an increasing level of OC-STAMP in AEC2 of silicotic rats. Overexpression of Ocstamp in MLE-12 cells promoted epithelial-mesenchymal transition (EMT), endoplasmic reticulum (ER) stress, and cellular senescence. Myosin heavy chain 9 (MYH9) was a potential interacting protein of OC-STAMP. Knockdown of Ocstamp or Myh9 inhibited cellular senescence in MLE-12 cells transfected with pcmv6-Ocstamp. Treatment with 4-phenylbutyrate (4-PBA) to inhibit ER stress also attenuated cellular senescence in vitro or in vivo. In conclusion, OC-STAMP promotes cellular senescence in AEC2 in silicosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicosis / Regulación de la Expresión Génica / Senescencia Celular / Células Epiteliales Alveolares / Proteínas de la Membrana Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicosis / Regulación de la Expresión Génica / Senescencia Celular / Células Epiteliales Alveolares / Proteínas de la Membrana Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos