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SARS-COV-2 seroprevalence among all healthcare workers in a tertiary hospital in Spain.
Cantero, Mireia; Millán-Pérez, Rosario; Muñez, Elena; Gómez-Lozano, Natalia; Anel-Pedroche, Jorge; Parra, Lina M; Rodríguez, Maria L; Asensio, Angel.
Afiliación
  • Cantero M; Department of Preventive Medicine, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Millán-Pérez R; Department of Microbiology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Muñez E; Department of Infectious Diseases, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Gómez-Lozano N; Department of Immunology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Anel-Pedroche J; Department of Microbiology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Parra LM; Department of Preventive Medicine, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Rodríguez ML; Department of Occupational Health, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Asensio A; Department of Preventive Medicine, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
Infect Dis (Lond) ; 54(1): 8-15, 2022 01.
Article en En | MEDLINE | ID: mdl-34424122
BACKGROUND: Healthcare workers (HCWs) have been a critical and vulnerable population during SARS-CoV-2 pandemic. The aim of this study was to determine the overall seroprevalence and to evaluate occupational risk factors among HCWs in one of the countries most affected by this pandemic. METHODS: We conducted a seroprevalence study for SARS-CoV-2 in a tertiary hospital in Madrid (Spain) between 24 April and 8 May 2020. A total of 4894 HCWs were invited for serologic testing. Serum samples were tested for SARS-CoV-2 IgM and IgG antibodies using Enzyme Immunoassay (ELISA) and Electro-Chemiluminescence Immunoassay (ECLIA) techniques. We calculated odds ratios to assess association between demographic and occupational characteristics with SARS-CoV-2 seroconversion. RESULTS: We processed 4324 serum samples. Overall, seroprevalence was of 16.6% (95% CI: 15.5-17.7). We found statistically significant differences in SARS-CoV-2 seroprevalence by type of employee, professional category, department and type of activity performed during the pandemic period, while no differences were identified between the personnel working in the COVID-19 wards compared to those working in non-COVID-19 wards. We confirmed 268 (26.7%) infections among 1005 hospital staff members tested by PCR. 60.5% of HCWs infected by SARS-CoV-2, assessed either by PCR or serology, could be considered asymptomatic or paucisymptomatic. CONCLUSIONS: HCWs have an increased risk of SARS-CoV-2 infection but COVID-19 patient exposure was not a determining factor. Universal mask wearing should be mandatory in healthcare settings given the important number of asymptomatic and paucisymptomatic cases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Infect Dis (Lond) Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Infect Dis (Lond) Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido