The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators.

Lopes, Ana P; Bekker, Cornelis P J; Hillen, Maarten R; Blokland, Sofie L M; Hinrichs, Anneline C; Pandit, Aridaman; Kruize, Aike A; Radstake, Timothy R D J; van Roon, Joel A G

Lopes, Ana P; Bekker, Cornelis P J; Hillen, Maarten R; Blokland, Sofie L M; Hinrichs, Anneline C; Pandit, Aridaman; Kruize, Aike A; Radstake, Timothy R D J; van Roon, Joel A G.

Afiliación

Lopes AP; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Bekker CPJ; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Hillen MR; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Blokland SLM; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Hinrichs AC; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Pandit A; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Kruize AA; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Radstake TRDJ; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
van Roon JAG; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Front Immunol ; 12: 701656, 2021.

Article en En | MEDLINE | ID: mdl-34413853

Asunto(s)

Inflamación/genética; Monocitos/patología; Síndrome de Sjögren/genética; Síndrome de Sjögren/patología; Transcriptoma/genética; Adulto; Anciano; Anciano de 80 o más Años; Autoanticuerpos/genética; Femenino; Humanos; Mediadores de Inflamación/metabolismo; Interferón Tipo I/genética; Receptores de Lipopolisacáridos/genética; Masculino; Persona de Mediana Edad; Transducción de Señal/genética; Receptores Toll-Like/genética; Adulto Joven

Palabras clave

Sjögren's syndrome; WGCNA; monocytes; systemic mediators; transcriptome; type-I interferons

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monocitos / Síndrome de Sjögren / Transcriptoma / Inflamación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza

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