Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery.

Hunter, Mandana; Spiller, Krista J; Dominique, Myrna A; Xu, Hong; Hunter, Francis W; Fang, Terry C; Canter, Rebecca G; Roberts, Christopher J; Ransohoff, Richard M; Trojanowski, John Q; Lee, Virginia M-Y

Hunter, Mandana; Spiller, Krista J; Dominique, Myrna A; Xu, Hong; Hunter, Francis W; Fang, Terry C; Canter, Rebecca G; Roberts, Christopher J; Ransohoff, Richard M; Trojanowski, John Q; Lee, Virginia M-Y.

Afiliación

Hunter M; Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-2676, USA.
Spiller KJ; Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-2676, USA.
Dominique MA; Janssen Research and Development, Spring House, PA, USA.
Xu H; Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-2676, USA.
Hunter FW; Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-2676, USA.
Fang TC; School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Canter RG; Janssen Research and Development, Spring House, PA, USA.
Roberts CJ; Biogen, Cambridge, MA, USA.
Ransohoff RM; Biogen, Cambridge, MA, USA.
Trojanowski JQ; Dementia Discovery Fund, SV Health Managers LLP, London, UK.
Lee VM; Biogen, Cambridge, MA, USA.

Acta Neuropathol Commun ; 9(1): 140, 2021 08 19.

Article en En | MEDLINE | ID: mdl-34412701

Asunto(s)

Esclerosis Amiotrófica Lateral/genética; Corteza Cerebral/metabolismo; Proteínas de Unión al ADN/genética; Microglía/metabolismo; Médula Espinal/metabolismo; Esclerosis Amiotrófica Lateral/metabolismo; Animales; Corteza Cerebral/citología; Quimiotaxis/genética; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Perfilación de la Expresión Génica; Humanos; Estudios Longitudinales; Ratones; Ratones Transgénicos; Enfermedades Neuroinflamatorias/genética; Neuroprotección/genética; Fagocitosis; RNA-Seq; Recuperación de la Función; Médula Espinal/citología; Proteinopatías TDP-43/genética; Proteinopatías TDP-43/metabolismo

Palabras clave

ALS; Amyotrophic lateral sclerosis; Microglia; Neurodegeneration; Neuroinflammation; Phagocytosis; Proteinopathy; Recovery; TDP-43; rNLS8

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Corteza Cerebral / Microglía / Proteínas de Unión al ADN / Esclerosis Amiotrófica Lateral Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Acta Neuropathol Commun Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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