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The effects of dexketoprofen on renal ischemia-reperfusion injury: an experimental study.
Koksal, Ersin; Ustun, Yasemin Burcu; Bilgin, Sezgin; Aksoy, Abdurrahman; Das, Yavuz Kursad; Yarim, Murat; Ozkan, Fatih; Kaya, Cengiz; Dost, Burhan.
Afiliación
  • Koksal E; Ondokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey. Electronic address: ersin.koksal@omu.edu.tr.
  • Ustun YB; Ondokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
  • Bilgin S; Ondokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
  • Aksoy A; Ondokuz Mayis University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Samsun, Turkey.
  • Das YK; Ondokuz Mayis University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Samsun, Turkey.
  • Yarim M; Ondokuz Mayis University, Faculty of Veterinary Medicine, Department of Pathology, Samsun, Turkey.
  • Ozkan F; Ondokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
  • Kaya C; Ondokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
  • Dost B; Ondokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
Braz J Anesthesiol ; 72(3): 365-371, 2022.
Article en En | MEDLINE | ID: mdl-34411625
OBJECTIVE: Ischemia/reperfusion (I/R) may cause irreversible damage to tissues and organs. We evaluated the effects of dexketoprofen on a renal I/R model in rats. METHODS: The study included 30 male rats. Control group received 1 mL of saline. Dexketoprofen group received 1 mL (25 mg) of dexketoprofen intraperitoneally. After 60 minutes renal ischemia, 23 hours reperfusion was applied. In Sham group, laparotomy was performed with a medial line incision without any additional procedure. Changes in the plasma malondialdehyde (MDA), renal tissue MDA, plasma glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), BUN, creatinine and albumin levels, and histopathological changes were evaluated. RESULTS: CAT values were significantly lower in Control as compared with the Sham group. Plasma levels of MDA in the Control group were significantly higher than in the Dexketoprofen group. BUN and creatinine values were significantly higher in the Dexketoprofen group. The severity of tissue injury in the Dexketoprofen group was significantly higher than in Control and Sham groups CONCLUSION: Although dexketoprofen reduces the I/R-induced systemic inflammation, it increases renal tissue damage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Límite: Animals / Humans / Male Idioma: En Revista: Braz J Anesthesiol Año: 2022 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Límite: Animals / Humans / Male Idioma: En Revista: Braz J Anesthesiol Año: 2022 Tipo del documento: Article Pais de publicación: Brasil