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Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial.
Manor, Brad; Dagan, Moria; Herman, Talia; Gouskova, Natalia A; Vanderhorst, Veronique G; Giladi, Nir; Travison, Thomas G; Pascual-Leone, Alvaro; Lipsitz, Lewis A; Hausdorff, Jeffrey M.
Afiliación
  • Manor B; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
  • Dagan M; Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Herman T; Harvard Medical School, Boston, Massachusetts, USA.
  • Gouskova NA; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Vanderhorst VG; Sagol School of Neuroscience and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Giladi N; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Travison TG; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
  • Pascual-Leone A; Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Lipsitz LA; Harvard Medical School, Boston, Massachusetts, USA.
  • Hausdorff JM; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Mov Disord ; 36(11): 2693-2698, 2021 11.
Article en En | MEDLINE | ID: mdl-34406695
BACKGROUND: Treatments of freezing of gait (FOG) in Parkinson's disease are suboptimal. OBJECTIVE: The aim of this study was to evaluate the effects of multiple sessions of transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex and primary motor cortex (M1) on FOG. METHODS: Seventy-seven individuals with Parkinson's disease and FOG were enrolled in a double-blinded randomized trial. tDCS and sham interventions comprised 10 sessions over 2 weeks followed by five once-weekly sessions. FOG-provoking test performance (primary outcome), functional outcomes, and self-reported FOG severity were assessed. RESULTS: Primary analyses demonstrated no advantage for tDCS in the FOG-provoking test. In secondary analyses, tDCS, compared with sham, decreased self-reported FOG severity and increased daily living step counts. Among individuals with mild-to-moderate FOG severity, tDCS improved FOG-provoking test time and self-report of FOG. CONCLUSIONS: Multisession tDCS targeting the left dorsolateral prefrontal cortex and M1 did not improve laboratory-based FOG-provoking test performance. Improvements observed in participants with mild-to-moderate FOG severity warrant further investigation. © 2021 International Parkinson and Movement Disorder Society.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha / Estimulación Transcraneal de Corriente Directa / Corteza Motora Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha / Estimulación Transcraneal de Corriente Directa / Corteza Motora Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos