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Bacterial infections in patients hospitalized with COVID-19.
Moreno-Torres, Víctor; de Mendoza, Carmen; de la Fuente, Sara; Sánchez, Enrique; Martínez-Urbistondo, María; Herráiz, Jesús; Gutiérrez, Andrea; Gutiérrez, Ángela; Hernández, Carlos; Callejas, Alejandro; Maínez, Carmen; Royuela, Ana; Cuervas-Mons, Valentín.
Afiliación
  • Moreno-Torres V; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain. victor.moreno.torres.1998@gmail.com.
  • de Mendoza C; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain. cmendoza.cdm@gmail.com.
  • de la Fuente S; CEU-San Pablo, University, Madrid, Spain. cmendoza.cdm@gmail.com.
  • Sánchez E; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Martínez-Urbistondo M; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Herráiz J; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Gutiérrez A; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Gutiérrez Á; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Hernández C; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Callejas A; Pharmacy Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Maínez C; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Royuela A; Internal Medicine Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Cuervas-Mons V; Clinical Biostatistics Unit, Health Research Institute Puerta de Hierro-Segovia de Arana, CIBERESP, Madrid, Spain.
Intern Emerg Med ; 17(2): 431-438, 2022 03.
Article en En | MEDLINE | ID: mdl-34406633
Bacterial infections may complicate the course of COVID-19 patients. The rate and predictors of bacterial infections were examined in patients consecutively admitted with COVID-19 at one tertiary hospital in Madrid between March 1st and April 30th, 2020. Among 1594 hospitalized patients with COVID-19, 135 (8.5%) experienced bacterial infectious events, distributed as follows: urinary tract infections (32.6%), bacteremia (31.9%), pneumonia (31.8%), intra-abdominal infections (6.7%) and skin and soft tissue infections (6.7%). Independent predictors of bacterial infections were older age, neurological disease, prior immunosuppression and ICU admission (p < 0.05). Patients with bacterial infections who more frequently received steroids and tocilizumab, progressed to lower Sap02/FiO2 ratios, and experienced more severe ARDS (p < 0.001). The mortality rate was significantly higher in patients with bacterial infections as compared to the rest (25% vs 6.7%, respectively; p < 0.001). In multivariate analyses, older age, prior neurological or kidney disease, immunosuppression and ARDS severity were associated with an increased mortality (p < 0.05) while bacterial infections were not. Conversely, the use of steroids or steroids plus tocilizumab did not confer a higher risk of bacterial infections and improved survival rates. Bacterial infections occurred in 8.5% of patients hospitalized with COVID-19 during the first wave of the pandemic. They were not independently associated with increased mortality rates. Baseline COVID-19 severity rather than the incidence of bacterial infections seems to contribute to mortality. When indicated, the use of steroids or steroids plus tocilizumab might improve survival in this population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / Infecciones Bacterianas / COVID-19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Intern Emerg Med Asunto de la revista: MEDICINA DE EMERGENCIA / MEDICINA INTERNA Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / Infecciones Bacterianas / COVID-19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Intern Emerg Med Asunto de la revista: MEDICINA DE EMERGENCIA / MEDICINA INTERNA Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia