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IL-17A-producing sinonasal MAIT cells in patients with chronic rhinosinusitis with nasal polyps.
Rha, Min-Seok; Yoon, Young Hoon; Koh, June-Young; Jung, Jae Hyung; Lee, Ha Seok; Park, Soo Kyoung; Park, Su-Hyung; Kim, Yong Min; Rha, Ki-Sang; Shin, Eui-Cheol.
Afiliación
  • Rha MS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea; Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
  • Yoon YH; Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Korea.
  • Koh JY; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
  • Jung JH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
  • Lee HS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
  • Park SK; Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Korea.
  • Park SH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
  • Kim YM; Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Korea; Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Korea. Electronic address: entkym@cnu.ac.kr.
  • Rha KS; Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Korea. Electronic address: ksrha@cnu.ac.kr.
  • Shin EC; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. Electronic address: ecshin@kaist.ac.kr.
J Allergy Clin Immunol ; 149(2): 599-609.e7, 2022 02.
Article en En | MEDLINE | ID: mdl-34403659
BACKGROUND: Diverse immune cells contribute to the pathogenesis of chronic rhinosinusitis (CRS), an inflammatory disease of the nasal cavity and paranasal sinuses. However, whether mucosal-associated invariant T (MAIT) cells are present in human sinonasal tissues remains unclear. Furthermore, the characteristics of sinonasal MAIT cells have not been studied in patients with CRS. OBJECTIVE: We investigated the phenotype, function, and clinical implications of MAIT cells in patients with CRS. METHODS: Peripheral blood and sinonasal tissue were obtained from patients with CRS with (CRSwNP) or without nasal polyps (CRSsNP) and healthy controls. MAIT cells were analyzed by flow cytometry. RESULTS: We found that MAIT cells are present in human sinonasal tissues from healthy controls and patients with CRS. The sinonasal MAIT cell population, but not peripheral blood MAIT cells, from patients with CRSsNP, noneosinophilic CRSwNP (NE-NP), or eosinophilic CRSwNP (E-NP) had a significantly higher frequency of activated cells marked by CD38 expression. In functional analysis, the sinonasal MAIT cell population from NE-NP and E-NP had a significantly higher frequency of IL-17A+ cells but lower frequency of IFN-γ+ or TNF+ cells than control sinonasal tissues. Furthermore, CD38 expression and IL-17A production by sinonasal MAIT cells significantly correlated with disease extent evaluated by the Lund-Mackay computed tomography score in patients with E-NP. CONCLUSIONS: Sinonasal MAIT cells exhibit an activated phenotype and produce higher levels of IL-17A in patients with CRSwNP. These alterations are associated with the extent of disease in patients with E-NP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senos Paranasales / Sinusitis / Rinitis / Pólipos Nasales / Interleucina-17 / Células T Invariantes Asociadas a Mucosa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senos Paranasales / Sinusitis / Rinitis / Pólipos Nasales / Interleucina-17 / Células T Invariantes Asociadas a Mucosa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos