Your browser doesn't support javascript.
loading
High mobility group box-1 serves a pathogenic role in spinal cord injury via the promotion of pro-inflammatory cytokines.
Chen, Ke-Bing; Chang, Min-Min; Wang, Sheng-Li; Li, Yong-Xin; Wang, Yi-Xi; Xu, Zhi-Guang; Wang, Hong; Zhao, Bing-Cheng; Ma, Wei-Ying.
Afiliación
  • Chen KB; Department of Spine Surgery, Center for Orthopaedic Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.
  • Chang MM; College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, P.R. China.
  • Wang SL; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, Guangdong, P.R. China.
  • Li YX; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, P.R. China.
  • Wang YX; Vascular Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P.R. China.
  • Xu ZG; Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China.
  • Wang H; Department of Spine Surgery, Center for Orthopaedic Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.
  • Zhao BC; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Disease, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China.
  • Ma WY; Department of Anesthesiology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China.
J Leukoc Biol ; 110(6): 1131-1142, 2021 12.
Article en En | MEDLINE | ID: mdl-34402106
Traumatic spinal cord injury (SCI) is a devastating condition marked by permanent motor, sensory, and autonomic dysfunction, in which the inflammatory response serves an important and preventable role. High mobility group box-1 (HMGB1) is a potent regulator of inflammation in numerous acute and chronic inflammatory conditions.; however, the role of HMGB1 in SCI remains unclear. The present study aimed to characterize the temporal dynamics of HMGB1 release after SCI, to investigate the role of spinal microglia activation in mediating the effects of HMGB1 on SCI, and to explore the therapeutic potential of intrathecal anti-HMGB1 polyclonal antibody on alleviating SCI. The present study demonstrated that HMGB1 expression was increased immediately after traumatic injury of a primary spinal neuron culture. It was found that neutralizing HMGB1 significantly ameliorated SCI pathogenesis and hind limb paralysis. Moreover, the levels of a number of pro-inflammatory cytokines in the SCI lesion were reduced when local HMGB1 was blocked by anti-HMGB1 antibody. In addition, the injured neuron-derived conditioned medium increased TNF-α secretion and the NF-κB pathway in the BV2 microglia cell line via HMGB1. Collectively, these results indicated that HMGB1 served an important role in SCI inflammation and suggested the therapeutic potential of an anti-HMGB1 antibody for SCI.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Proteína HMGB1 Límite: Animals Idioma: En Revista: J Leukoc Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Proteína HMGB1 Límite: Animals Idioma: En Revista: J Leukoc Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido