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SARS-CoV-2 Seroprevalence and Drug Use in Trauma Patients from Six Sites in the United States.
Ngo, Tran B; Karkanitsa, Maria; Adusei, Kenneth M; Graham, Lindsey A; Ricotta, Emily E; Darrah, Jenna R; Blomberg, Richard D; Spathies, Jacquelyn; Pauly, Kyle J; Klumpp-Thomas, Carleen; Travers, Jameson; Mehalko, Jennifer; Drew, Matthew; Hall, Matthew D; Memoli, Matthew J; Esposito, Dominic; Kozar, Rosemary A; Griggs, Christopher; Cunningham, Kyle W; Schulman, Carl I; Crandall, Marie; Neavyn, Mark; Dorfman, Jon D; Lai, Jeffrey T; Whitehill, Jennifer M; Babu, Kavita M; Mohr, Nicholas M; Van Heukelom, Jon; Fell, James C; Rooke, Whit; Kalish, Heather; Thomas, F Dennis; Sadtler, Kaitlyn.
Afiliación
  • Ngo TB; Section on Immuno-Engineering. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20894.
  • Karkanitsa M; Section on Immuno-Engineering. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20894.
  • Adusei KM; Section on Immuno-Engineering. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20894.
  • Graham LA; Dunlap and Associates, Inc., Stamford CT 06906.
  • Ricotta EE; Epidemiology and Population Studies Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20894.
  • Darrah JR; Dunlap and Associates, Inc., Stamford CT 06906.
  • Blomberg RD; Dunlap and Associates, Inc., Stamford CT 06906.
  • Spathies J; Bioengineering and Physical Sciences Shared Resource, National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20894.
  • Pauly KJ; Bioengineering and Physical Sciences Shared Resource, National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20894.
  • Klumpp-Thomas C; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville MD 20852.
  • Travers J; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville MD 20852.
  • Mehalko J; Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, Frederick MD 21702.
  • Drew M; Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, Frederick MD 21702.
  • Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville MD 20852.
  • Memoli MJ; Clinical Studies Unit, Laboratory of Infectious Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20894.
  • Esposito D; Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, Frederick MD 21702.
  • Kozar RA; Shock Trauma Center, University of Maryland School of Medicine, Baltimore MD 21201.
  • Griggs C; Department of Emergency Medicine, Atrium Health's Carolinas Medical Center, Charlotte NC 28203.
  • Cunningham KW; Division of Acute Care Surgery, Atrium Health's Carolinas Medical Center, Charlotte NC 28203.
  • Schulman CI; University of Miami Miller School of Medicine, Miami FL 33136.
  • Crandall M; Department of Surgery, University of Florida College of Medicine, Jacksonville FL 33209.
  • Neavyn M; Department of Emergency Medicine, University of Massachusetts Medical School, Worcester MA 01655.
  • Dorfman JD; Maine Medical Center, Department of Emergency Medicine, Tufts University School of Medicine, Portland ME 04102.
  • Lai JT; Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester MA 01655.
  • Whitehill JM; Department of Health Promotion and Policy, University of Massachusetts Amherst, Amherst MA 01003.
  • Babu KM; Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester MA 01655.
  • Mohr NM; Department of Emergency Medicine, Anesthesia Critical Care, and Epidemiology, University of Iowa Health Care, Iowa City IA 52242.
  • Van Heukelom J; Department of Emergency Medicine, University of Iowa Health Care, Iowa City IA 52242.
  • Fell JC; NORC at the University of Chicago, Bethesda, MD 20814.
  • Rooke W; KIYATEC, Inc., Greenville SC 29605.
  • Kalish H; Bioengineering and Physical Sciences Shared Resource, National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20894.
  • Thomas FD; Dunlap and Associates, Inc., Stamford CT 06906.
  • Sadtler K; Section on Immuno-Engineering. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda MD 20894.
medRxiv ; 2021 Aug 11.
Article en En | MEDLINE | ID: mdl-34401892
In comparison to the general patient population, trauma patients show higher level detections of bloodborne infectious diseases, such as Hepatitis and Human Immunodeficiency Virus. In comparison to bloodborne pathogens, the prevalence of respiratory infections such as SARS-CoV-2 and how that relates with other variables, such as drug usage and trauma type, is currently unknown in trauma populations. Here, we evaluated SARS-CoV-2 seropositivity and antibody isotype profile in 2,542 trauma patients from six Level-1 trauma centers between April and October of 2020 during the first wave of the COVID-19 pandemic. We found that the seroprevalence in trauma victims 18-44 years old (9.79%, 95% confidence interval/CI: 8.33 - 11.47) was much higher in comparison to older patients (45-69 years old: 6.03%, 4.59-5.88; 70+ years old: 4.33%, 2.54 - 7.20). Black/African American (9.54%, 7.77 - 11.65) and Hispanic/Latino patients (14.95%, 11.80 - 18.75) also had higher seroprevalence in comparison, respectively, to White (5.72%, 4.62 - 7.05) and Non-Latino patients (6.55%, 5.57 - 7.69). More than half (55.54%) of those tested for drug toxicology had at least one drug present in their system. Those that tested positive for narcotics or sedatives had a significant negative correlation with seropositivity, while those on anti-depressants trended positive. These findings represent an important consideration for both the patients and first responders that treat trauma patients facing potential risk of respiratory infectious diseases like SARS-CoV-2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos