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Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria.
Garcha, Damanpreet; Walker, Susan P; MacDonald, Teresa M; Hyett, Jon; Jellins, Jessica; Myers, Jenny; Illanes, Sebastian E; Nien, Jhy K; Schepeler, Manuel; Keenan, Emerson; Whigham, Carole-Anne; Cannon, Ping; Murray, Elizabeth; Nguyen, Tuong-Vi; Kandel, Manju; Masci, Joshua; Murphy, Ciara; Cruickshank, Tess; Pritchard, Natasha; Hannan, Natalie J; Brownfoot, Fiona; Roddy Mitchell, Alexandra; Middleton, Anna; Pell, Gabrielle; Wong, Georgia P; Tong, Stephen; Kaitu'u-Lino, Tu'uhevaha J.
Afiliación
  • Garcha D; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Walker SP; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • MacDonald TM; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Hyett J; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Jellins J; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Myers J; Sydney Institute for Women, Children and Their Families, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia.
  • Illanes SE; Sydney Institute for Women, Children and Their Families, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia.
  • Nien JK; University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Manchester, M13 OJH, UK.
  • Schepeler M; Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de Los Andes, San Carlos de Apoquindo 2200, Las Condes, Santiago de Chile, Chile.
  • Keenan E; Department of Obstetrics and Gynaecology, Clínica Davila, Recoleta 464, Recoleta, Santiago, Chile.
  • Whigham CA; Department of Obstetrics and Gynaecology, Clínica Davila, Recoleta 464, Recoleta, Santiago, Chile.
  • Cannon P; Department of Obstetrics and Gynaecology, Clínica Davila, Recoleta 464, Recoleta, Santiago, Chile.
  • Murray E; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Nguyen TV; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Kandel M; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Masci J; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Murphy C; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Cruickshank T; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Pritchard N; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Hannan NJ; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Brownfoot F; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Roddy Mitchell A; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Middleton A; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Pell G; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Wong GP; Mercy Perinatal, Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Tong S; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
  • Kaitu'u-Lino TJ; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, VIC, 3084, Australia.
Sci Rep ; 11(1): 16595, 2021 08 16.
Article en En | MEDLINE | ID: mdl-34400721
Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomarkers may improve detection of pregnancies at risk. This study aimed to assess syndecan-1 as a biomarker for small for gestational age (SGA) or fetal growth restricted (FGR) pregnancies and determine its molecular regulation. Circulating maternal syndecan-1 was measured in several cohorts; a large prospective cohort collected around 36 weeks' gestation (n = 1206), a case control study from the Manchester Antenatal Vascular service (285 women sampled at 24-34 weeks' gestation); two prospective cohorts collected on the day of delivery (36 + 3-41 + 3 weeks' gestation, n = 562 and n = 405 respectively) and a cohort who delivered for preterm FGR (< 34 weeks). Circulating syndecan-1 was consistently reduced in women destined to deliver growth restricted infants and those delivering for preterm disease. Syndecan-1 secretion was reduced by hypoxia, and its loss impaired proliferation. Matrix metalloproteinases and mitochondrial electron transport chain inhibitors significantly reduced syndecan-1 secretion, an effect that was rescued by coadministration of succinate, a mitochondrial electron transport chain activator. In conclusion, circulating syndecan-1 is reduced among cases of term and preterm growth restriction and has potential for inclusion in multi-marker algorithms to improve detection of poorly grown fetuses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Complicaciones del Embarazo / Metaloproteinasas de la Matriz / Sindecano-1 / Retardo del Crecimiento Fetal / Mitocondrias Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Complicaciones del Embarazo / Metaloproteinasas de la Matriz / Sindecano-1 / Retardo del Crecimiento Fetal / Mitocondrias Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido