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Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Ghazy, Ehab; Heimburg, Tino; Lancelot, Julien; Zeyen, Patrik; Schmidtkunz, Karin; Truhn, Anne; Darwish, Salma; Simoben, Conrad V; Shaik, Tajith B; Erdmann, Frank; Schmidt, Matthias; Robaa, Dina; Romier, Christophe; Jung, Manfred; Pierce, Raymond; Sippl, Wolfgang.
Afiliación
  • Ghazy E; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Heimburg T; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Lancelot J; University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017- CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France.
  • Zeyen P; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Schmidtkunz K; Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany.
  • Truhn A; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Darwish S; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Simoben CV; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Shaik TB; Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Biologie Structurale Intégrative, 67404, Illkirch Cedex, France.
  • Erdmann F; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Schmidt M; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Robaa D; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany.
  • Romier C; Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Département de Biologie Structurale Intégrative, 67404, Illkirch Cedex, France.
  • Jung M; Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany.
  • Pierce R; University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017- CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France.
  • Sippl W; Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120, Halle/Saale, Germany. Electronic address: wolfgang.sippl@pharmazie.uni-halle.de.
Eur J Med Chem ; 225: 113745, 2021 Dec 05.
Article en En | MEDLINE | ID: mdl-34392190
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis / Inhibidores de Histona Desacetilasas / Histona Desacetilasas Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis / Inhibidores de Histona Desacetilasas / Histona Desacetilasas Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Francia