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A low serum IGF-1 is correlated with sarcopenia in subjects with type 1 diabetes mellitus: Findings from a post-hoc analysis of the iDIAMOND study.
Hata, Sonyun; Mori, Hiroyasu; Yasuda, Tetsuyuki; Irie, Yoko; Yamamoto, Tsunehiko; Umayahara, Yutaka; Ryomoto, Kayoko; Yoshiuchi, Kazutomi; Yoshida, Sumiko; Shimomura, Iichiro; Kuroda, Akio; Matsuhisa, Munehide.
Afiliación
  • Hata S; Department of Endocrinology and Metabolism, Osaka Police Hospital, Osaka, Japan.
  • Mori H; Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
  • Yasuda T; Department of Endocrinology and Metabolism, Osaka Police Hospital, Osaka, Japan.
  • Irie Y; Department of Endocrinology and Metabolism, Osaka Police Hospital, Osaka, Japan.
  • Yamamoto T; Kansai Rosai Hospital, Hyogo, Japan.
  • Umayahara Y; Osaka General Medical Center, Osaka, Japan.
  • Ryomoto K; Osaka Rosai Hospital, Osaka, Japan.
  • Yoshiuchi K; Osaka Kaisei Hospital, Osaka, Japan.
  • Yoshida S; Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
  • Shimomura I; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
  • Kuroda A; Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
  • Matsuhisa M; Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan. Electronic address: matuhisa@tokushima-u.ac.jp.
Diabetes Res Clin Pract ; 179: 108998, 2021 Sep.
Article en En | MEDLINE | ID: mdl-34390761
AIM: Our previous study revealed that sarcopenia was frequently observed in subjects with type 1 diabetes mellitus (T1DM). However, the factors associated with sarcopenia that are related to T1DM have not yet been clarified. Insulin-like growth factor-1 (IGF-1) has been shown to play a role in skeletal muscle growth, differentiation, and regeneration. The present study, therefore, investigated the association between the serum IGF-1 level and sarcopenia and low skeletal muscle mass in subjects with T1DM. METHODS: This cross-sectional study enrolled subjects with T1DM (n = 168) and without diabetes (n = 59) who had had their clinical data on serum IGF-1 collected in the iDIAMOND study. RESULTS: The z-score of serum IGF-1 was significantly lower in the subjects with T1DM than that in those without diabetes (p < 0.001). Among subjects with T1DM, the z-score of serum IGF-1 was significantly lower in sarcopenic subjects than in non-sarcopenic subjects. The multivariable logistic regression analysis showed that the serum IGF-1 z-score was an independent determinant of sarcopenia and a low skeletal muscle mass index, but not low grip strength nor slow gait speed in subjects with T1DM. CONCLUSIONS: A low serum IGF-1 level is correlated with sarcopenia and low skeletal muscle mass in subjects with T1DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Diabetes Mellitus Tipo 1 / Sarcopenia Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Diabetes Mellitus Tipo 1 / Sarcopenia Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda