Your browser doesn't support javascript.
loading
Concurrent cardiac transthyretin and brain ß amyloid accumulation among the older adults: The Hisayama study.
Hamasaki, Hideomi; Shijo, Masahiro; Nakamura, Ayaka; Honda, Hiroyuki; Yamada, Yuichi; Oda, Yoshinao; Ohara, Tomoyuki; Ninomiya, Toshiharu; Iwaki, Toru.
Afiliación
  • Hamasaki H; Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Shijo M; Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Nakamura A; Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan.
  • Honda H; Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Yamada Y; Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Oda Y; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Ohara T; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Ninomiya T; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Iwaki T; Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Brain Pathol ; 32(1): e13014, 2022 01.
Article en En | MEDLINE | ID: mdl-34390072
Previous studies have revealed risk for cognitive impairment in cardiovascular diseases. We investigated the relationship between degenerative changes of the brain and heart, with reference to Alzheimer's disease (AD) pathologies, cardiac transthyretin amyloid (ATTR) deposition, and cardiac fibrosis. A total of 240 consecutive autopsy cases of a Japanese population-based study were examined. ß amyloid (Aß) of senile plaques, phosphorylated tau protein of neurofibrillary tangles, and ATTR in the hearts were immunohistochemically detected and graded according to the NIH-AA guideline for AD pathology and as Tanskanen reported, respectively. Cerebral amyloid angiopathy (CAA) was graded according to the Vonsattel scale. Cardiac fibrosis was detected by picrosirius red staining, followed by image analysis. Cardiac ATTR deposition occurred after age 75 years and increased in an age-dependent manner. ATTR deposition was more common, and of higher grades, in the dementia cases. We subdivided the cases into two age groups: ≤90 years old (n = 173) and >90 years old (n = 67), which was the mean and median age at death of the AD cases. When adjusted for age and sex, TTR deposition grades correlated with Aß phase score (A2-3), the Consortium to Establish a Registry for AD score (sparse to frequent), and high Braak stage (V-VI) only in those aged ≤90 years at death. No significant correlation was observed between the cardiac ATTR deposition and CAA stages, or between cardiac fibrosis and AD pathologies. Collectively, AD brain pathology correlated with cardiac TTR deposition among the older adults ≤90 years.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiopatía Amiloide Cerebral / Enfermedad de Alzheimer Límite: Aged / Aged80 / Humans Idioma: En Revista: Brain Pathol Asunto de la revista: CEREBRO / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiopatía Amiloide Cerebral / Enfermedad de Alzheimer Límite: Aged / Aged80 / Humans Idioma: En Revista: Brain Pathol Asunto de la revista: CEREBRO / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza