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Anaerobic biotransformation mechanism of marine toxin domoic acid.
Du, Miaomiao; Li, Zelong; Wang, Jing; Wang, Fengbo; Zan, Shuaijun; Gu, Chen.
Afiliación
  • Du M; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, PR China.
  • Li Z; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, PR China.
  • Wang J; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, PR China. Electronic address: jwang@dlut.edu.cn.
  • Wang F; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, PR China.
  • Zan S; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, PR China.
  • Gu C; Power China Huadong Engineering Corporation Limited, Hangzhou 311122, China.
J Hazard Mater ; 421: 126798, 2022 01 05.
Article en En | MEDLINE | ID: mdl-34388926
Domoic acid (DA) is a major marine neurotoxin, occurs frequently in most of the world's coastlines and seriously threatens ecosystem and public health. However, information on its biotransformation process in coastal anaerobic environments remains unclear. In this study, the underlying mechanism of anaerobic biotransformation of DA by marine consortium GLY was investigated using the combination of liquid chromatography-high-resolution Orbitrap mass spectrometry and comparative metatranscriptomics analysis. The results demonstrated that DA could be cometabolically biotransformed under anaerobic conditions with pseudo-first-order reaction. Anaerobic biotransformation pathway of DA was clarified, including decarboxylation, dehydrogenation, carboxylation activation with CoA and multiple ß-oxidation steps occurring at aliphatic side chain, which facilitated DA detoxification. Furthermore, anaerobic cometabolic biotransformation mechanism of glycine-DA by consortium GLY was established for the first time, a number of genes related to the metabolic pathways of glycine fermentation, fatty acid synthesis and ß-oxidation were responded in the consortium GLY transcriptome and involved in the anaerobic biotransformation of DA. This study could deepen understanding of interaction mechanism between toxin DA and marine microorganisms, which provides a new insight into the DA fate and its effects on benthic microbial community in marine environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecosistema / Toxinas Marinas Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecosistema / Toxinas Marinas Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos