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Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential.
Grafakou, Maria-Eleni; Barda, Christina; Pintac, Diandra; Lesjak, Marija; Heilmann, Jörg; Skaltsa, Helen.
Afiliación
  • Grafakou ME; Department of Pharmacognosy & Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece.
  • Barda C; Chair of Pharmaceutical Biology, Faculty of Pharmacy and Chemistry, University of Regensburg, Germany.
  • Pintac D; Department of Pharmacognosy & Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece.
  • Lesjak M; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Serbia.
  • Heilmann J; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Serbia.
  • Skaltsa H; Chair of Pharmaceutical Biology, Faculty of Pharmacy and Chemistry, University of Regensburg, Germany.
Planta Med ; 87(14): 1184-1191, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34388832
Thirteen prenylated acylphloroglucinols (1: -13: ), including 2 previously undescribed compounds (1: ) and (2: ), were isolated from Hypericum jovis. Their structures were elucidated by high-field NMR spectroscopy. The isolated prenylated acylphloroglucinols were evaluated for their anti-inflammatory effects in vitro through the reduction of the intercellular adhesion molecule 1 expression induced by TNF-α in the human microvascular endothelial cells 1 cell line. Compounds 3, 5, 6, 8,: and 12: significantly reduced intercellular adhesion molecule 1 expression in a concentration-dependent manner with IC50 values of 16.9, 34.4, 4.0, 3.2, and 7.7 µM, respectively. In addition, compound 12: showed notable inhibitory activity on the formation of cyclooxygenase-1- and 12-lipoxygenase-derived inflammatory mediators in an ex vivo cyclooxygenase-lipoxygenase assay. Eleven further constituents were isolated (14: -24: ), including the rare quercetin 3-O-(2-O-acetyl)-arabinofuranoside (18: ).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hypericum Idioma: En Revista: Planta Med Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hypericum Idioma: En Revista: Planta Med Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania