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Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
Lee, Min-Woo; Lim, Hyung-Bin; Koo, Hyung-Moon; Lee, Young-Hoon; Kim, Jung-Yeul.
Afiliación
  • Lee MW; Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Republic of Korea.
  • Lim HB; Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
  • Koo HM; Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
  • Lee YH; Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Republic of Korea.
  • Kim JY; Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
PLoS One ; 16(8): e0256131, 2021.
Article en En | MEDLINE | ID: mdl-34388218
PURPOSE: To identify the impacts of hypertension (HTN), high myopia, and the combination thereof on peripapillary retinal nerve fiber layer (pRNFL) thickness. METHODS: All subjects were divided into four groups: control (group 1); patients with HTN without high myopia (group 2); patients with high myopia without HTN (group 3); and patients with both HTN and high myopia (group 4). The pRNFL thicknesses were compared using a one-way analysis of variance. Univariate and multivariate linear regression analyses were used to identify factors affecting pRNFL thickness in subjects with and without HTN. RESULTS: The mean pRNFL thicknesses were 93.9±8.8, 88.7±6.8, 86.4±8.1, and 82.5±9.6 µm in group 1, 2, 3, and 4, respectively, and differed significantly (P<0.001). On multivariate linear regression analyses, age (ß = -0.181, P = 0.044), axial length (ß = -1.491, P<0.001), and HTN (ß = -4.876, P = 0.044) significantly affected pRNFL thickness. Additionally, age and axial length affected the pRNFL thickness in subjects with HTN (age, ß = -0.254, P = 0.020; axial length, ß = -1.608, P<0.001) much more than in subjects without HTN (age, ß = -0.028, P = 0.712; axial length, ß = -1.324, P<0.001). CONCLUSIONS: High myopia and HTN affected pRNFL reduction and a combination of the 2 diseases exacerbated pRNFL damage. This could be a confounding factor in interpreting pRNFL thickness in patients with ophthalmic diseases affecting the pRNFL thickness when combined with the 2 diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retina / Agudeza Visual / Hipertensión / Presión Intraocular / Miopía / Fibras Nerviosas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retina / Agudeza Visual / Hipertensión / Presión Intraocular / Miopía / Fibras Nerviosas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos