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After Thirty Years, We Still Cannot Understand Why Methylene Blue is not a Reference to Treat Vasoplegic Syndrome in Cardiac Surgery.
Evora, Paulo Roberto B; Soares, Ricardo O S; Bassetto, Solange; Auxiliadora-Martins, Maria; Silva, Fábio Luis da Silva; Basile, Anibal.
Afiliación
  • Evora PRB; Department of Surgery & Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Soares ROS; Faculdade de Medicina de Marília, Marília, São Paulo, Brazil.
  • Bassetto S; Department of Surgery & Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Auxiliadora-Martins M; Department of Surgery & Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Silva FLDS; Department of Surgery & Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Basile A; Department of Surgery & Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Braz J Cardiovasc Surg ; 36(3): 406-411, 2021 06 01.
Article en En | MEDLINE | ID: mdl-34387976
Vasoplegic syndrome (VS) comprises a constellation of concurrent signs and symptoms: hypotension, high cardiac index, low systemic vascular resistance, low filling pressures, the tendency to occur diffuse bleeding, and sustained hypotension. All of these parameters may persist even despite the use of high doses of vasoconstrictor amines. VS arises from vasoplegic endothelial dysfunction with excessive release of nitric oxide by polymorphonuclear leukocytes mediated by the nitric oxide synthase's inducible form and is associated with systemic inflammatory reaction and high morbimortality. The achievements regarding the treatment of VS with methylene blue (MB) are a valuable Brazilian contribution to cardiac surgery. The present text review was designed to deliver the accumulated knowledge in the past ten years of employing MB to treat VS after cardiac surgery. Considering that we have already published two papers describing acquired experiences and concepts after 15 and 20 years, now, as we achieve the 30-year mark, we compose a trilogy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasoplejía / Procedimientos Quirúrgicos Cardíacos / Hipotensión Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Braz J Cardiovasc Surg Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasoplejía / Procedimientos Quirúrgicos Cardíacos / Hipotensión Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Braz J Cardiovasc Surg Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil