Your browser doesn't support javascript.
loading
Eosinophil extracellular traps in a patient with chronic eosinophilic pneumonia.
Takeda, Masahide; Sakamoto, Sho; Ueki, Shigeharu; Miyabe, Yui; Fukuchi, Mineyo; Okuda, Yuji; Asano, Mariko; Sato, Kazuhiro; Nakayama, Katsutoshi.
Afiliación
  • Takeda M; Department of Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Sakamoto S; Department of Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Ueki S; Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Miyabe Y; Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Fukuchi M; Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Okuda Y; Department of Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Asano M; Department of Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Sato K; Department of Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
  • Nakayama K; Department of Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Asia Pac Allergy ; 11(3): e24, 2021 Jul.
Article en En | MEDLINE | ID: mdl-34386400
Eosinophils rapidly release extracellular filamentous chromatin fibers (extracellular traps, ETs) when they are stimulated. Reticulated ETs have been recently shown to affect secretion viscosity in eosinophilic inflammatory diseases. Here we report a 43-year-old woman with infiltrative shadows in both upper lungs that did not respond well to antibiotics. She admitted to occasional coughing and sputum, but had poor viscous regulation. Bronchoalveolar lavage fluid (BALF) collected from the upper left lobe showed many eosinophils (65%). She was diagnosed with chronic eosinophilic pneumonia, per previously reported criteria, and began treatment with prednisolone. The infiltration shadow gradually improved, and she was discharged 28 days after admission. Later, we immune-stained her BALF cell components with antibodies against major basic protein, an eosinophil granule protein, which showed a large number of agglomerating eosinophils; and antibodies against citrullinated histone H3 (CitH3-a marker for ETs), which showed CitH3-positive ETs, spread in a network. These findings confirmed that some BALF eosinophils released eosinophil ETs. This case shows the existence of ETs from BALF in patients with chronic eosinophilic pneumonia. Concentration of eosinophil ETs in eosinophilic inflammatory diseases may affect secretion viscosity in sputum, and so on.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asia Pac Allergy Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asia Pac Allergy Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos