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WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss.
Damen, Pim J J; Bulthuis, Vincent J; Hanssens, Patrick E J; Lie, Suan Te; Fleischeuer, Ruth; Melotte, Veerle; Wouters, Kim A; Ruland, Andrea; Beckervordersandforth, Jan; Speel, Ernst Jan M.
Afiliación
  • Damen PJJ; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, Maastricht, The Netherlands.
  • Bulthuis VJ; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.
  • Hanssens PEJ; Gamma Knife Center Tilburg, ETZ-Elisabeth Hospital, Tilburg, The Netherlands.
  • Lie ST; Gamma Knife Center Tilburg, ETZ-Elisabeth Hospital, Tilburg, The Netherlands.
  • Fleischeuer R; Department of Pathology, ETZ-Elisabeth Hospital, Tilburg, The Netherlands.
  • Melotte V; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, Maastricht, The Netherlands.
  • Wouters KA; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, Maastricht, The Netherlands.
  • Ruland A; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, Maastricht, The Netherlands.
  • Beckervordersandforth J; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, Maastricht, The Netherlands.
  • Speel EJM; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, Maastricht, The Netherlands. ernstjan.speel@mumc.nl.
Sci Rep ; 11(1): 16432, 2021 08 12.
Article en En | MEDLINE | ID: mdl-34385566
WHO grade I meningiomas occasionally show regrowth after radiosurgical treatment, which cannot be predicted by clinical features. There is increasing evidence that certain biomarkers are associated with regrowth of meningiomas. The aim of this retrospective study was to asses if these biomarkers could be of value to predict regrowth of WHO grade I meningiomas after additive radiosurgery. Forty-four patients with WHO grade I meningiomas who underwent additive radiosurgical treatment between 2002 and 2015 after Simpson IV resection were included in this study, of which 8 showed regrowth. Median follow-up time was 64 months (range 24-137 months). Tumors were analyzed for the proliferation marker Ki-67 by immunohistochemistry and for deletion of 1p36 by fluorescence in situ hybridization (FISH). Furthermore, genomic DNA was analyzed for promoter hypermethylation of the genes NDRG1-4, SFRP1, HOXA9 and MGMT. Comparison of meningiomas with and without regrowth after radiosurgery revealed that loss of 1p36 (p = 0.001) and hypermethylation of NDRG1 (p = 0.046) were correlated with regrowth free survival. Loss of 1p36 was the only parameter that was significantly associated with meningioma regrowth after multivariate analysis (p = 0.01). Assessment of 1p36 loss in tumor tissue prior to radiosurgery might be considered an indicator of prognosis/regrowth. However, this finding has to be validated in an independent larger set of tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 1 / Deleción Cromosómica / Radiocirugia / Neoplasias Meníngeas / Meningioma / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 1 / Deleción Cromosómica / Radiocirugia / Neoplasias Meníngeas / Meningioma / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido