Atherosclerotic Renovascular Disease: A KDIGO (Kidney Disease: Improving Global Outcomes) Controversies Conference.
Am J Kidney Dis
; 79(2): 289-301, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-34384806
The diagnosis and management of atherosclerotic renovascular disease (ARVD) is complex and controversial. Despite evidence from the ASTRAL (2009) and CORAL (2013) randomized controlled trials showing that percutaneous renal artery revascularization did not improve major outcomes compared with best medical therapy alone over 3-5 years, several areas of uncertainty remain. Medical therapy, including statin and antihypertensive medications, has evolved in recent years, and the use of renin-angiotensin-aldosterone system blockers is now considered the primary means to treat hypertension in the setting of ARVD. However, the criteria to identify kidneys with renal artery stenosis that have potentially salvageable function are evolving. There are also data suggesting that certain high-risk populations with specific clinical manifestations may benefit from revascularization. Here, we provide an overview of the epidemiology, diagnosis, and treatment of ARVD based on consensus recommendations from a panel of physician experts who attended the recent KDIGO (Kidney Disease: Improving Global Outcomes) Controversies Conference on central and peripheral arterial diseases in chronic kidney disease. Most focus is provided for contentious issues, and we also outline aspects of investigation and management of ARVD that require further research.
Palabras clave
Atherosclerotic renovascular disease (ARVD); RAAS blockade; blood pressure control; chronic kidney disease (CKD); fibromuscular dysplasia (FMD); heart failure (HF); ischemic nephropathy; renal artery stenosis (RAS); renin-angiotensin-aldosterone system (RAAS); revascularization; treatment recommendations
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Obstrucción de la Arteria Renal
/
Aterosclerosis
/
Hipertensión Renovascular
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
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Guideline
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Kidney Dis
Año:
2022
Tipo del documento:
Article
Pais de publicación:
Estados Unidos