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Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses.
Wang, Xinrui; Song, Weiyi; Ji, Guanyu; Song, Yining; Liu, Xiaolei; Luo, Xuenong; Liu, Mingyuan; Sun, Shumin.
Afiliación
  • Wang X; College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, 028000, Inner Mongolia, China.
  • Song W; College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, 028000, Inner Mongolia, China.
  • Ji G; Shenzhen E-GENE Technology Co., LTD, B3301, Life Science Park, Shenzhen City Construction Investment Development Creative Factory, Julongshan A Road, Pingshan District, Shenzhen, 518083, China.
  • Song Y; College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, 028000, Inner Mongolia, China.
  • Liu X; Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130000, China.
  • Luo X; Lanzhou Institute of Veterinary Medicine, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, China.
  • Liu M; College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, 028000, Inner Mongolia, China. liumy@jlu.edu.cn.
  • Sun S; Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130000, China. liumy@jlu.edu.cn.
Hereditas ; 158(1): 28, 2021 Aug 12.
Article en En | MEDLINE | ID: mdl-34384501
BACKGROUND: The life cycle of Taenia solium is characterized by different stages of development, requiring various kinds of hosts that can appropriately harbor the eggs (proglottids), the oncospheres, the larvae and the adults. Similar to other metazoan pathogens, T. solium undergoes transcriptional and developmental regulation via epigenetics during its complex lifecycle and host interactions. RESULT: In the present study, we integrated whole-genome bisulfite sequencing and RNA-seq technologies to characterize the genome-wide DNA methylation and its effect on transcription of Cysticercus cellulosae of T. solium. We confirm that the T. solium genome in the cysticercus stage is epigenetically modified by DNA methylation in a pattern similar to that of other invertebrate genomes, i.e., sparsely or moderately methylated. We also observed an enrichment of non-CpG methylation in defined genetic elements of the T. solium genome. Furthermore, an integrative analysis of both the transcriptome and the DNA methylome indicated a strong correlation between these two datasets, suggesting that gene expression might be tightly regulated by DNA methylation. Importantly, our data suggested that DNA methylation might play an important role in repressing key parasitism-related genes, including genes encoding excretion-secretion proteins, thereby raising the possibility of targeting DNA methylation processes as a useful strategy in therapeutics of cysticercosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Taenia solium / Genoma de los Helmintos Límite: Animals Idioma: En Revista: Hereditas Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Taenia solium / Genoma de los Helmintos Límite: Animals Idioma: En Revista: Hereditas Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido