Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca<sup>2+</sup> Overload and Autophagy Inhibition.

Wang, Xuan; Li, Yunhao; Deng, Xiongwei; Jia, Fan; Cui, Xinyue; Lu, Jianqing; Pan, Zian; Wu, Yan

Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca²⁺ Overload and Autophagy Inhibition.

Wang, Xuan; Li, Yunhao; Deng, Xiongwei; Jia, Fan; Cui, Xinyue; Lu, Jianqing; Pan, Zian; Wu, Yan.

Afiliación

Wang X; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Li Y; University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Deng X; Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China.
Jia F; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Cui X; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Lu J; University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Pan Z; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Wu Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.

ACS Appl Mater Interfaces ; 13(33): 39112-39125, 2021 Aug 25.

Article en En | MEDLINE | ID: mdl-34384220

Asunto(s)

Autofagia/efectos de los fármacos; Fosfatos de Calcio/química; Glucosa/química; Indoles/química; Nanocompuestos/química; Fosfatidiletanolaminas/química; Fármacos Fotosensibilizantes/química; Polietilenglicoles/química; Animales; Transporte Biológico; Refuerzo Biomédico; Femenino; Humanos; Indoles/metabolismo; Indoles/farmacología; Ratones Endogámicos BALB C; Mitocondrias/metabolismo; Mitocondrias/ultraestructura; Neoplasias/diagnóstico por imagen; Neoplasias/terapia; Fosfolípidos/química; Fotoquimioterapia; Fármacos Fotosensibilizantes/farmacología; Pirroles/química; Pirroles/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal; Propiedades de Superficie; Distribución Tisular

Palabras clave

DSPE-PEG-glucose; ROS; autophagy inhibition; calcium phosphate; mitochondrial Ca2+ overload; photodynamic therapy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidiletanolaminas / Polietilenglicoles / Autofagia / Fosfatos de Calcio / Fármacos Fotosensibilizantes / Nanocompuestos / Glucosa / Indoles Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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