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Genetic Variation of Glutathione S-Transferase M1 Is Associated with Patients with Ovarian Endometriosis and Endometriosis-Related Primary Infertility.
Zhang, Hai-Bo; Li, Yan; Wu, Jian-Lei; Zhao, Jian; Tian, Yun-Jie; Kang, Shan.
Afiliación
  • Zhang HB; Department of Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
  • Li Y; Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
  • Wu JL; Department of Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
  • Zhao J; Department of Gynaecology, First Hospital of Shijiazhuang, Shijiazhuang, China.
  • Tian YJ; Department of Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
  • Kang S; Department of Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
Public Health Genomics ; 24(5-6): 261-266, 2021.
Article en En | MEDLINE | ID: mdl-34384077
BACKGROUND: The aim of the study was to investigate the role of the genetic variation of glutathione S-transferase M1 (GSTM1) in the development of ovarian endometriosis and endometriosis-related primary infertility risk. METHODS: This case-control study included 564 women with ovarian endometriosis and 576 normal women in the control group in northern China. The polymorphism of GSTM1 was genotyped by polymerase chain reaction (PCR)/ligase detection reaction method. To assess the biological significance of polymorphisms, the level of GSTM1 mRNA expression in patients' endometrial tissues with different genotypes was detected by quantitative real-time PCR (qRT-PCR). RESULTS: Compared with the positive genotype, the null genotype of GSTM1 was associated with the risk of developing ovarian endometriosis (OR = 1.29, 95% CI = 1.02-1.62). Further analysis showed that patients with a null genotype also had a significantly higher risk of primary infertility than patients with positive genotypes (OR = 1.59, 95% CI = 1.01-2.49). In addition, we found that GSTM1 mRNA expression was present in the endometrial tissue of all patients, but the expression level of patients with a positive genotype was nearly 10 times higher than that of patients with a negative genotype. CONCLUSION: Our results suggest that the GSTM1 polymorphism is not only related to the genetic susceptibility to ovarian endometriosis but also a potential molecular marker of primary infertility in patients with ovarian endometriosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endometriosis Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Public Health Genomics Asunto de la revista: GENETICA MEDICA / SAUDE PUBLICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endometriosis Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Public Health Genomics Asunto de la revista: GENETICA MEDICA / SAUDE PUBLICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza