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Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
Heinrich, Timo; Sala-Hojman, Ada; Ferretti, Roberta; Petersson, Carl; Minguzzi, Stefano; Gondela, Andrzej; Ramaswamy, Shivapriya; Bartosik, Anna; Czauderna, Frank; Crowley, Lindsey; Wahra, Pamela; Schilke, Heike; Böpple, Pia; Dudek, Lukasz; Les, Marcin; Niedziejko, Paulina; Olech, Kamila; Pawlik, Henryk; Wloszczak, Lukasz; Zuchowicz, Karol; Suarez Alvarez, Jose Ramon; Martyka, Justyna; Sitek, Ewa; Mikulski, Maciej; Szczesniak, Joanna; Jäckel, Sven; Krier, Mireille; Król, Marcin; Wegener, Ansgar; Galezowski, Michal; Nowak, Mateusz; Becker, Frank; Herhaus, Christian.
Afiliación
  • Heinrich T; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Sala-Hojman A; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Ferretti R; EMD Serono Research & Development Institute, Inc., 45A Middlesex Turnpike, Billerica, Massachusetts 01821, United States.
  • Petersson C; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Minguzzi S; Intana, Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Martinsried, Germany.
  • Gondela A; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Ramaswamy S; EMD Serono Research & Development Institute, Inc., 45A Middlesex Turnpike, Billerica, Massachusetts 01821, United States.
  • Bartosik A; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Czauderna F; EMD Serono Research & Development Institute, Inc., 45A Middlesex Turnpike, Billerica, Massachusetts 01821, United States.
  • Crowley L; EMD Serono Research & Development Institute, Inc., 45A Middlesex Turnpike, Billerica, Massachusetts 01821, United States.
  • Wahra P; EMD Serono Research & Development Institute, Inc., 45A Middlesex Turnpike, Billerica, Massachusetts 01821, United States.
  • Schilke H; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Böpple P; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Dudek L; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Les M; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Niedziejko P; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Olech K; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Pawlik H; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Wloszczak L; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Zuchowicz K; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Suarez Alvarez JR; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Martyka J; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Sitek E; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Mikulski M; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Szczesniak J; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Jäckel S; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Krier M; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Król M; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Wegener A; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Galezowski M; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Nowak M; Ryvu Therapeutics, Sternbacha 2, 30-394 Kraków, Poland.
  • Becker F; Intana, Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Martinsried, Germany.
  • Herhaus C; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
J Med Chem ; 64(16): 11904-11933, 2021 08 26.
Article en En | MEDLINE | ID: mdl-34382802
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Picolínicos / Sulfonamidas / Transportadores de Ácidos Monocarboxílicos / Proteínas Musculares / Neoplasias / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Picolínicos / Sulfonamidas / Transportadores de Ácidos Monocarboxílicos / Proteínas Musculares / Neoplasias / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos