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A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity.
Nilsson, Per H; Johnson, Christina; Quach, Quang Huy; Macpherson, Alex; Durrant, Oliver; Pischke, Soeren E; Fure, Hilde; Landsem, Anne; Bergseth, Grethe; Schjalm, Camilla; Haugaard-Kedström, Linda M; Huber-Lang, Markus; van den Elsen, Jean; Brekke, Ole-Lars; Mollnes, Tom Eirik.
Afiliación
  • Nilsson PH; Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Johnson C; Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
  • Quach QH; Department of Chemistry and Biomedical Sciences, Linnaeus University, Kalmar, Sweden.
  • Macpherson A; Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Durrant O; Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Pischke SE; UCB, Slough, UK.
  • Fure H; Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.
  • Landsem A; UCB, Slough, UK.
  • Bergseth G; Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.
  • Schjalm C; Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Haugaard-Kedström LM; Clinic for Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
  • Huber-Lang M; Research Laboratory, Nordland Hospital, Bodø, Norway.
  • van den Elsen J; Research Laboratory, Nordland Hospital, Bodø, Norway.
  • Brekke OL; Faculty of Health Sciences, K. G. Jebsen Thrombosis Research Center, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
  • Mollnes TE; Research Laboratory, Nordland Hospital, Bodø, Norway.
J Immunol ; 207(6): 1641-1651, 2021 09 15.
Article en En | MEDLINE | ID: mdl-34380648
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C5 / Trombina Límite: Humans Idioma: En Revista: J Immunol Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C5 / Trombina Límite: Humans Idioma: En Revista: J Immunol Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos