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HDL and persistent inflammation immunosuppression and catabolism syndrome.
Barker, Grant; Winer, Julia R; Guirgis, Faheem W; Reddy, Srinivasa.
Afiliación
  • Barker G; Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville.
  • Winer JR; University of Florida College of Medicine, Gainesville, Florida.
  • Guirgis FW; Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville.
  • Reddy S; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.
Curr Opin Lipidol ; 32(5): 315-322, 2021 10 01.
Article en En | MEDLINE | ID: mdl-34374677
PURPOSE OF REVIEW: This study reviews the mechanisms of HDL cholesterol immunomodulation in the context of the mechanisms of chronic inflammation and immunosuppression causing persistent inflammation, immunosuppression and catabolism syndrome (PICS) and describes potential therapies and gaps in current research. RECENT FINDINGS: Low HDL cholesterol is predictive of acute sepsis severity and outcome. Recent research has indicated apolipoprotein is a prognostic indicator of long-term outcomes. The pathobiologic mechanisms of PICS have been elucidated in the past several years. Recent research of the interaction of HDL pathways in related chronic inflammatory diseases may provide insights into further mechanisms and therapeutic targets. SUMMARY: HDL significantly influences innate and adaptive immune pathways relating to chronic disease and inflammation. Further research is needed to better characterize these interactions in the setting of PICS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Tolerancia Inmunológica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Curr Opin Lipidol Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Tolerancia Inmunológica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Curr Opin Lipidol Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido