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Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients.
Ding, Lingling; De Munck, Toon J I; Oligschlaeger, Yvonne; Verbeek, Jef; Koek, Ger H; Houben, Tom; Shiri-Sverdlov, Ronit.
Afiliación
  • Ding L; Department of Molecular Genetics, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229ER Maastricht, the Netherlands.
  • De Munck TJI; Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229ER Maastricht, the Netherlands.
  • Oligschlaeger Y; Department of Molecular Genetics, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229ER Maastricht, the Netherlands.
  • Verbeek J; Department of Gastroenterology & Hepatology, University Hospitals KU Leuven, Leuven, Belgium.
  • Koek GH; Department of visceral and transplantation surgery, Klinikum, RWTH, Aachen, Germany.
  • Houben T; Department of Molecular Genetics, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229ER Maastricht, the Netherlands.
  • Shiri-Sverdlov R; Department of Molecular Genetics, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, 6229ER Maastricht, the Netherlands.
Biomol Concepts ; 12(1): 110-115, 2021 Aug 09.
Article en En | MEDLINE | ID: mdl-34370929
Previous studies associated plasma cathepsin D (CTSD) activity with hepatic insulin resistance in overweight and obese humans. Insulin resistance is a major feature of non-alcoholic fatty liver disease (NAFLD) and is one of the multiple hits determining the progression towards non-alcoholic steatohepatitis (NASH). In line, we have previously demonstrated that plasma CTSD levels are increased in NASH patients. However, it is not known whether insulin resistance associates with plasma CTSD activity in NAFLD. To increase our understanding regarding the mechanisms by which insulin resistance mediates NAFLD, fifty-five liver biopsy or MRI-proven NAFLD patients (BMI>25kg/m2) were included to investigate the link between plasma CTSD activity to insulin resistance in NAFLD. We concluded that HOMA-IR and plasma insulin levels are independently associated with plasma CTSD activity in NAFLD patients (standardized coefficient ß: 0.412, 95% Cl: 0.142~0.679, p=0.004 and standardized coefficient ß: 0.495, 95% Cl: 0.236~0.758, p=0.000, respectively). Together with previous studies, these data suggest that insulin resistance may link to NAFLD via elevation of CTSD activity in plasma. As such, these data pave the way for testing CTSD inhibitors as a pharmacological treatment of NAFLD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Biomol Concepts Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Biomol Concepts Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania