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More than causing (epi)genomic instability: emerging physiological implications of transposable element modulation.
Hsu, Pu-Sheng; Yu, Shu-Han; Tsai, Yi-Tzang; Chang, Jen-Yun; Tsai, Li-Kuang; Ye, Chih-Hung; Song, Ning-Yu; Yau, Lih-Chiao; Lin, Shau-Ping.
Afiliación
  • Hsu PS; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
  • Yu SH; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
  • Tsai YT; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
  • Chang JY; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
  • Tsai LK; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
  • Ye CH; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
  • Song NY; Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
  • Yau LC; Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
  • Lin SP; Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
J Biomed Sci ; 28(1): 58, 2021 Aug 07.
Article en En | MEDLINE | ID: mdl-34364371
Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as well as regulatory sequences to cause disease. Host cells have therefore evolved various epigenetic and functional RNA-mediated mechanisms to mitigate the disruption of genomic integrity by TEs. TE associated sequences therefore acquire the tendencies of attracting various epigenetic modifiers to induce epigenetic alterations that may spread to the neighboring genes. In addition to posting threats for (epi)genome integrity, emerging evidence suggested the physiological importance of endogenous TEs either as cis-acting control elements for controlling gene regulation or as TE-containing functional transcripts that modulate the transcriptome of the host cells. Recent advances in long-reads sequence analysis technologies, bioinformatics and genetic editing tools have enabled the profiling, precise annotation and functional characterization of TEs despite their challenging repetitive nature. The importance of specific TEs in preimplantation embryonic development, germ cell differentiation and meiosis, cell fate determination and in driving species specific differences in mammals will be discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Elementos Transponibles de ADN / Regulación de la Expresión Génica / Inestabilidad Genómica / Epigénesis Genética Límite: Animals / Humans Idioma: En Revista: J Biomed Sci Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Elementos Transponibles de ADN / Regulación de la Expresión Génica / Inestabilidad Genómica / Epigénesis Genética Límite: Animals / Humans Idioma: En Revista: J Biomed Sci Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido