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Redox Active Cerium Oxide Nanoparticles: Current Status and Burning Issues.
Lord, Megan S; Berret, Jean Francois; Singh, Sanjay; Vinu, Ajayan; Karakoti, Ajay S.
Afiliación
  • Lord MS; Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, New South Wales, 2052, Australia.
  • Berret JF; Matière et systèmes complexes, Université de Paris, CNRS, Paris, 75013, France.
  • Singh S; National Institute of Animal Biotechnology, Hyderabad, Telangana, 500032, India.
  • Vinu A; Global Innovative Center for Advanced Nanomaterials, College of Engineering Science and Environment, The University of Newcastle, Callaghan, New South Wales, 2308, Australia.
  • Karakoti AS; Global Innovative Center for Advanced Nanomaterials, College of Engineering Science and Environment, The University of Newcastle, Callaghan, New South Wales, 2308, Australia.
Small ; 17(51): e2102342, 2021 12.
Article en En | MEDLINE | ID: mdl-34363314
Research on cerium oxide nanoparticles (nanoceria) has captivated the scientific community due to their unique physical and chemical properties, such as redox activity and oxygen buffering capacity, which made them available for many technical applications, including biomedical applications. The redox mimetic antioxidant properties of nanoceria have been effective in the treatment of many diseases caused by reactive oxygen species (ROS) and reactive nitrogen species. The mechanism of ROS scavenging activity of nanoceria is still elusive, and its redox activity is controversial due to mixed reports in the literature showing pro-oxidant and antioxidant activity. In light of its current research interest, it is critical to understand the behavior of nanoceria in the biological environment and provide answers to some of the critical and open issues. This review critically analyzes the status of research on the application of nanoceria to treat diseases caused by ROS. It reviews the proposed mechanism of action and shows the effect of surface coatings on its redox activity. It also discusses some of the crucial issues in deciphering the mechanism and redox activity of nanoceria and suggests areas of future research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cerio / Nanopartículas Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cerio / Nanopartículas Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania