A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma.

Tavares, Monique C; Sampaio, Cristina D; Lima, Geraldine E; Andrade, Victor P; Gonçalves, Daniel G; Macedo, Mariana P; Cordeiro de Lima, Vladmir C

A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma.

Tavares, Monique C; Sampaio, Cristina D; Lima, Geraldine E; Andrade, Victor P; Gonçalves, Daniel G; Macedo, Mariana P; Cordeiro de Lima, Vladmir C.

Afiliación

Tavares MC; Department of Medical Oncology, AC Camargo Cancer Center, Rua Professor Antonio Prudente 211, ZIP:01525-001, São Paulo, SP, Brazil. monique.tavares@accamargo.org.br.
Sampaio CD; Department of Medical Oncology, AC Camargo Cancer Center, Rua Professor Antonio Prudente 211, ZIP:01525-001, São Paulo, SP, Brazil.
Lima GE; Department of Medical Oncology, AC Camargo Cancer Center, Rua Professor Antonio Prudente 211, ZIP:01525-001, São Paulo, SP, Brazil.
Andrade VP; Department of Anatomic Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
Gonçalves DG; Laboratory of Bioinformatics, International Center for Teaching and Research AC Camargo Cancer Center, São Paulo, Brazil.
Macedo MP; Departament of Anatomic Pathology, Hospital Sírio Libanês, São Paulo, Brazil.
Cordeiro de Lima VC; Department of Medical Oncology, AC Camargo Cancer Center, Rua Professor Antonio Prudente 211, ZIP:01525-001, São Paulo, SP, Brazil.

BMC Cancer ; 21(1): 901, 2021 Aug 06.

Article en En | MEDLINE | ID: mdl-34362334

Asunto(s)

Antígenos CD8/metabolismo; Factores de Transcripción Forkhead/metabolismo; Linfocitos Infiltrantes de Tumor/metabolismo; Fosfohidrolasa PTEN/genética; Neoplasias de la Mama Triple Negativas/etiología; Neoplasias de la Mama Triple Negativas/metabolismo; Microambiente Tumoral; Antígeno B7-H1/metabolismo; Biomarcadores de Tumor; Femenino; Expresión Génica; Humanos; Inmunohistoquímica; Estimación de Kaplan-Meier; Recuento de Linfocitos; Linfocitos Infiltrantes de Tumor/inmunología; Clasificación del Tumor; Estadificación de Neoplasias; Pronóstico; Neoplasias de la Mama Triple Negativas/diagnóstico; Neoplasias de la Mama Triple Negativas/mortalidad; Microambiente Tumoral/inmunología

Palabras clave

CD8; FOXP3; Immune infiltrate; PTEN; Survival; Triple-negative breast cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos Infiltrantes de Tumor / Antígenos CD8 / Fosfohidrolasa PTEN / Factores de Transcripción Forkhead / Microambiente Tumoral / Neoplasias de la Mama Triple Negativas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido

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