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PlasmiR: A Manual Collection of Circulating microRNAs of Prognostic and Diagnostic Value.
Tastsoglou, Spyros; Miliotis, Marios; Kavakiotis, Ioannis; Alexiou, Athanasios; Gkotsi, Eleni C; Lambropoulou, Anastasia; Lygnos, Vasileios; Kotsira, Vasiliki; Maroulis, Vasileios; Zisis, Dimitrios; Skoufos, Giorgos; Hatzigeorgiou, Artemis G.
Afiliación
  • Tastsoglou S; Hellenic Pasteur Institute, 11521 Athens, Greece.
  • Miliotis M; DIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35131 Lamia, Greece.
  • Kavakiotis I; Hellenic Pasteur Institute, 11521 Athens, Greece.
  • Alexiou A; DIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35131 Lamia, Greece.
  • Gkotsi EC; DIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35131 Lamia, Greece.
  • Lambropoulou A; Hellenic Pasteur Institute, 11521 Athens, Greece.
  • Lygnos V; DIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35131 Lamia, Greece.
  • Kotsira V; Department of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
  • Maroulis V; Hellenic Pasteur Institute, 11521 Athens, Greece.
  • Zisis D; Hellenic Pasteur Institute, 11521 Athens, Greece.
  • Skoufos G; DIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35131 Lamia, Greece.
  • Hatzigeorgiou AG; Department of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
Cancers (Basel) ; 13(15)2021 Jul 22.
Article en En | MEDLINE | ID: mdl-34359584
Only recently, microRNAs (miRNAs) were found to exist in traceable and distinctive amounts in the human circulatory system, bringing forth the intriguing possibility of using them as minimally invasive biomarkers. miRNAs are short non-coding RNAs that act as potent post-transcriptional regulators of gene expression. Extensive studies in cancer and other disease landscapes investigate the protective/pathogenic functions of dysregulated miRNAs, as well as their biomarker potential. A specialized resource amassing experimentally verified, circulating miRNA biomarkers does not exist. We queried the existing literature to identify articles assessing diagnostic/prognostic roles of miRNAs in blood, serum, or plasma samples. Articles were scrutinized in order to exclude instances lacking sufficient experimental documentation or employing no biomarker assessment methods. We incorporated information from more than 200 biomedical articles, annotating crucial meta-information including cohort sizes, inclusion-exclusion criteria, disease/healthy confirmation methods and quantification details. miRNAs and diseases were systematically characterized using reference resources. Our circulating miRNA biomarker collection is provided as an online database, plasmiR. It consists of 1021 entries regarding 251 miRNAs and 112 diseases. More than half of plasmiR's entries refer to cancerous and neoplastic conditions, 183 of them (32%) describing prognostic associations. plasmiR facilitates smart queries, emphasizing visualization and exploratory modes for all researchers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza