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Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching.
Xu, Huan; Wu, Ziqiang; Jin, Zhong; Wu, Xiao; Hu, Wangming; Liang, Bing; Lou, Guanhua; Chen, Zixian; Yao, Huan; Chen, Xiongbing; Zhou, Xin; Xiao, Han; Yu, Cenghao; Zhang, Delai; Gong, Daoying; Yang, Lan; Shi, Yaping; Xu, Yiming; Wang, Yong.
Afiliación
  • Xu H; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Wu Z; College Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Jin Z; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Wu X; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Hu W; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Liang B; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Lou G; College Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Chen Z; School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Yao H; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Chen X; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Zhou X; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Xiao H; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Yu C; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Zhang D; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Gong D; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Yang L; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Shi Y; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Xu Y; School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
  • Wang Y; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
J Endovasc Ther ; 29(1): 117-131, 2022 02.
Article en En | MEDLINE | ID: mdl-34355606
OBJECTIVE: Smooth muscle cell (SMC) phenotypic switching is associated with development of a variety of occlusive vascular diseases. Paeonol has been reported to be involved in suppressing SMC proliferation. However, it is still unknown whether paeonol can regulate SMC phenotypic switching, and which eventually result in suppressing vasculogenesis. METHODS: Murine left common carotid artery was injured by completely ligation, and paeonol was administrated by intraperitoneal injection. Hematoxylin and eosin (H&E) staining was performed to visualize vascular neointima formation. Rat aortic SMCs were used to determine whether paeonol suppresses cell proliferation and migration. And murine hind limb ischemia model was performed to confirm the function role of paeonol in suppressing vasculogenesis. RESULTS: Complete ligation of murine common carotid artery successfully induced neointima formation. Paeonol treatment dramatically reduced the size of injury-induced neointima. Using rat aortic primary SMC, we identified that paeonol strongly suppressed cell proliferation, migration, and decreased extracellular matrix deposition. And paeonol treatment dramatically suppressed vasculogenesis after hind limb ischemia injury. CONCLUSION: Paeonol could regulate SMC phenotypic switching through inhibiting proliferation and migration of SMC, which results in inhibiting ischemia-induced vasculogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de las Arterias Carótidas / Músculo Liso Vascular Límite: Animals Idioma: En Revista: J Endovasc Ther Asunto de la revista: ANGIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de las Arterias Carótidas / Músculo Liso Vascular Límite: Animals Idioma: En Revista: J Endovasc Ther Asunto de la revista: ANGIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos