Your browser doesn't support javascript.
loading
Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia.
Viher, Petra Verena; Stegmayer, Katharina; Bracht, Tobias; Federspiel, Andrea; Bohlhalter, Stephan; Strik, Werner; Wiest, Roland; Walther, Sebastian.
Afiliación
  • Viher PV; Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland.
  • Stegmayer K; Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland.
  • Bracht T; Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland.
  • Federspiel A; Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland.
  • Bohlhalter S; Department of Clinical Research, University Hospital, Inselspital, Bern, Switzerland.
  • Strik W; Neurocenter, Luzerner Kantonsspital, Switzerland.
  • Wiest R; Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland.
  • Walther S; Support Center of Advanced Neuroimaging, Institute of Neuroradiology, University of Bern, Switzerland.
Schizophr Bull ; 48(1): 220-230, 2022 01 21.
Article en En | MEDLINE | ID: mdl-34355246
Neurological soft signs (NSS) are related to grey matter and functional brain abnormalities in schizophrenia. Studies in healthy subjects suggest, that NSS are also linked to white matter. However, the association between NSS and white matter abnormalities in schizophrenia remains to be elucidated. The present study investigated, if NSS are related to white matter alterations in patients with schizophrenia. The total sample included 42 healthy controls and 41 patients with schizophrenia. We used the Neurological Evaluation Scale (NES), and we acquired diffusion weighted magnetic resonance imaging to assess white matter on a voxel-wise between subject statistic. In patients with schizophrenia, linear associations between NES with fractional anisotropy (FA), radial, axial, and mean diffusivity were analyzed with tract-based spatial statistics while controlling for age, medication dose, the severity of the disease, and motion. The main pattern of results in patients showed a positive association of NES with all diffusion measures except FA in important motor pathways: the corticospinal tract, internal capsule, superior longitudinal fascicle, thalamocortical radiations and corpus callosum. In addition, exploratory tractography analysis revealed an association of the right aslant with NES in patients. These results suggest that specific white matter alterations, that is, increased diffusivity might contribute to NSS in patients with schizophrenia.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Sustancia Blanca / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Bull Año: 2022 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Sustancia Blanca / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Bull Año: 2022 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos