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Immune, Blood Cell, and Blood Gas Biomarkers of Delirium in Elderly Individuals with Hip Fracture Surgery.
Thisayakorn, Paul; Tangwongchai, Sookjaroen; Tantavisut, Saran; Thipakorn, Yanin; Sukhanonsawat, Siree; Wongwarawipat, Tanya; Sirivichayakul, Sunee; Maes, Michael.
Afiliación
  • Thisayakorn P; Department of Psychiatry, Hip Fracture Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Tangwongchai S; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Tantavisut S; Department of Orthopedics, Hip Fracture Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Thipakorn Y; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Sukhanonsawat S; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Wongwarawipat T; Nan District Hospital, Nan, Thailand.
  • Sirivichayakul S; Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Maes M; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Dement Geriatr Cogn Disord ; 50(2): 161-169, 2021.
Article en En | MEDLINE | ID: mdl-34350874
BACKGROUND: Postoperative delirium in elderly people with hip fracture is associated with various adverse clinical outcomes. Nevertheless, the pathophysiological processes underpinning delirium have remained elusive. OBJECTIVES: The aim of this study was to explore the associations between delirium and its features and immune-inflammatory and blood gas biomarkers. METHODS: In this prospective study, we examined 65 patients who underwent a hip fracture surgery and assessed the Confusion Assessment Method for the Intensive Care Unit, Richmond Agitation-Sedation Scale (RASS), and Delirium Rating Scale Revised-98 (DRS-R-98) before and during 4 days after the surgery. Complete blood count and venous blood gas markers were obtained at the same time points. RESULTS: Delirium was observed in 19 patients and was accompanied by significantly increased pO2, number of white blood cells, neutrophil percentage, and neutrophil/lymphocyte ratio, and lower mean platelet volume (MPV) after adjusting for age, central nervous system (CNS) disease, blood loss during surgery, sleep disorders, and body mass index. The severity of delirium was associated with lowered number of platelets and MPV. Psychomotor disorders were associated with lower bicarbonate levels. The requirement of physical restraint of the patients was predicted by increased percentages of neutrophils and lymphocytes. Prior CNS disease was together with these biomarkers a significant predictor of delirium and severity of delirium. CONCLUSION: Delirium and psychomotor disorders following hip fracture and surgery may be caused by immune-inflammatory and oxidative stress pathways probably attributable to an aseptic inflammatory process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delirio / Fracturas de Cadera Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Dement Geriatr Cogn Disord Asunto de la revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delirio / Fracturas de Cadera Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Dement Geriatr Cogn Disord Asunto de la revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza