Carotid sheath xanthoma: A rare manifestation of lipid disorders.
J Clin Lipidol
; 15(4): 574-578, 2021.
Article
en En
| MEDLINE
| ID: mdl-34344629
Xanthomas are visibly deformed cholesterol deposits that are commonly associated with lipid disorders, such as familial hypercholesterolemia (FH) or rare sitosterolemia. We present the first report of two cases of carotid sheath xanthomas in patients with lipid disorders. Case 1 involved a 26-year-old woman presenting with two heterogeneous mutations on the ABCG5 gene-as noted on genetic testing-who was finally diagnosed with sitosterolemia. Ultrasonography (US) revealed hypoechoic masses centered in the bilateral carotid sheath, which gradually reduced in size after diet control and the use of ezetimibe. Case 2 involved a 27-year-old man who was diagnosed with possible FH and had recurrent bilateral buttock xanthomas, as well as bilateral carotid sheath masses detected by US. Postoperative pathological examination of the resected right neck mass confirmed a xanthoma with proliferation of multinucleated giant cells and deposition of cholesterol clefts.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fitosteroles
/
Enfermedades de las Arterias Carótidas
/
Xantomatosis
/
Hipercolesterolemia
/
Hiperlipoproteinemia Tipo II
/
Enfermedades Intestinales
/
Errores Innatos del Metabolismo Lipídico
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Lipidol
Asunto de la revista:
BIOQUIMICA
/
METABOLISMO
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Estados Unidos